Eukaryotic transcriptional control - PubMed (original) (raw)
Affiliations
- PMID: 10611681
Free article
Review
Eukaryotic transcriptional control
R D Kornberg. Trends Cell Biol. 1999 Dec.
Free article
Abstract
Some 30 years ago, following the elucidation of transcriptional control in prokaryotes, attention turned to the corresponding problem in eukaryotes: how are so many genes transcribed in a cell-type-specific, developmentally regulated manner? The answer has been found in two modes of regulation, one involving chromatin and the other the chief transcribing enzyme, RNA polymerase II. Although basic features of the prokaryotic mechanism have been preserved, the demands of eukaryotic transcription control are met by a huge increase in complexity and by the addition of new layers to the transcription apparatus. Discovering the components of this apparatus has been a major theme of research over the past three decades; unravelling the mechanisms is a challenge for the future.
Similar articles
- Transcription elongation and eukaryotic gene regulation.
Spencer CA, Groudine M. Spencer CA, et al. Oncogene. 1990 Jun;5(6):777-85. Oncogene. 1990. PMID: 2193290 Review. - The transcriptional regulatory code of eukaryotic cells--insights from genome-wide analysis of chromatin organization and transcription factor binding.
Barrera LO, Ren B. Barrera LO, et al. Curr Opin Cell Biol. 2006 Jun;18(3):291-8. doi: 10.1016/j.ceb.2006.04.002. Epub 2006 May 2. Curr Opin Cell Biol. 2006. PMID: 16647254 Review. - Fundamentally different logic of gene regulation in eukaryotes and prokaryotes.
Struhl K. Struhl K. Cell. 1999 Jul 9;98(1):1-4. doi: 10.1016/S0092-8674(00)80599-1. Cell. 1999. PMID: 10412974 Review. No abstract available. - Gene expression in eukaryotes.
Brown DD. Brown DD. Oncodev Biol Med. 1982;4(1-2):9-29. Oncodev Biol Med. 1982. PMID: 6757878 Review. - Transcriptional noise and the evolution of gene number.
Bird A, Tweedie S. Bird A, et al. Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29;349(1329):249-53. doi: 10.1098/rstb.1995.0109. Philos Trans R Soc Lond B Biol Sci. 1995. PMID: 8577835
Cited by
- Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging.
Sen P, Donahue G, Li C, Egervari G, Yang N, Lan Y, Robertson N, Shah PP, Kerkhoven E, Schultz DC, Adams PD, Berger SL. Sen P, et al. Nat Aging. 2023 Apr;3(4):402-417. doi: 10.1038/s43587-023-00384-3. Epub 2023 Mar 30. Nat Aging. 2023. PMID: 37117791 Free PMC article. - CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue.
van Riet J, Saha C, Strepis N, Brouwer RWW, Martens-Uzunova ES, van de Geer WS, Swagemakers SMA, Stubbs A, Halimi Y, Voogd S, Tanmoy AM, Komor MA, Hoogstrate Y, Janssen B, Fijneman RJA, Niknafs YS, Chinnaiyan AM, van IJcken WFJ, van der Spek PJ, Jenster G, Louwen R. van Riet J, et al. Commun Biol. 2022 Apr 8;5(1):338. doi: 10.1038/s42003-022-03249-4. Commun Biol. 2022. PMID: 35396392 Free PMC article. - Switching promotor recognition of phage RNA polymerase in silico along lab-directed evolution path.
E C, Dai L, Yu J. E C, et al. Biophys J. 2022 Feb 15;121(4):582-595. doi: 10.1016/j.bpj.2022.01.007. Epub 2022 Jan 11. Biophys J. 2022. PMID: 35031277 Free PMC article. - Plant Responses to Biotic Stress: Old Memories Matter.
Bhar A, Chakraborty A, Roy A. Bhar A, et al. Plants (Basel). 2021 Dec 28;11(1):84. doi: 10.3390/plants11010084. Plants (Basel). 2021. PMID: 35009087 Free PMC article. Review. - Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer.
Ebersbach C, Beier AK, Thomas C, Erb HHH. Ebersbach C, et al. Cancers (Basel). 2021 Sep 28;13(19):4854. doi: 10.3390/cancers13194854. Cancers (Basel). 2021. PMID: 34638338 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous