Transport between the cell nucleus and the cytoplasm - PubMed (original) (raw)
Review
Transport between the cell nucleus and the cytoplasm
D Görlich et al. Annu Rev Cell Dev Biol. 1999.
Abstract
The compartmentation of eukaryotic cells requires all nuclear proteins to be imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and ribosomes are made in the nucleus and need to be exported to the cytoplasm. Nuclear import and export proceed through nuclear pore complexes and can occur along a great number of distinct pathways, many of which are mediated by importin beta-related nuclear transport receptors. These receptors shuttle between nucleus and cytoplasm, and they bind transport substrates either directly or via adapter molecules. They all cooperate with the RanGTPase system to regulate the interactions with their cargoes. Another focus of our review is nuclear export of messenger RNA, which apparently largely relies on export mediators distinct from importin beta-related factors. We discuss mechanistic aspects and the energetics of transport receptor function and describe a number of pathways in detail.
Similar articles
- Transport of macromolecules between the nucleus and the cytoplasm.
Izaurralde E, Adam S. Izaurralde E, et al. RNA. 1998 Apr;4(4):351-64. RNA. 1998. PMID: 9630243 Free PMC article. Review. - Mediators of nuclear protein import target karyophilic proteins to pore complexes of cytoplasmic annulate lamellae.
Cordes VC, Rackwitz HR, Reidenbach S. Cordes VC, et al. Exp Cell Res. 1997 Dec 15;237(2):419-33. doi: 10.1006/excr.1997.3806. Exp Cell Res. 1997. PMID: 9434638 - The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.
Izaurralde E, Kutay U, von Kobbe C, Mattaj IW, Görlich D. Izaurralde E, et al. EMBO J. 1997 Nov 3;16(21):6535-47. doi: 10.1093/emboj/16.21.6535. EMBO J. 1997. PMID: 9351834 Free PMC article. - Nucleocytoplasmic protein traffic and its significance to cell function.
Yoneda Y. Yoneda Y. Genes Cells. 2000 Oct;5(10):777-87. doi: 10.1046/j.1365-2443.2000.00366.x. Genes Cells. 2000. PMID: 11029654 Review.
Cited by
- Clock protein LHY targets SNAT1 and negatively regulates the biosynthesis of melatonin in Hypericum perforatum.
Zhou W, Xiao RY, Yang YX, Wang X, Wang DH, Wang ZZ. Zhou W, et al. Sci Adv. 2024 Sep 20;10(38):eadq6505. doi: 10.1126/sciadv.adq6505. Epub 2024 Sep 18. Sci Adv. 2024. PMID: 39292789 Free PMC article. - Elements of transcriptional machinery are compatible among plants and mammals.
Wolf A, Akrap N, Marg B, Galliardt H, Heiligentag M, Humpert F, Sauer M, Kaltschmidt B, Kaltschmidt C, Seidel T. Wolf A, et al. PLoS One. 2013;8(1):e53737. doi: 10.1371/journal.pone.0053737. Epub 2013 Jan 11. PLoS One. 2013. PMID: 23326494 Free PMC article. - Analysis of a Strong Suppressor of Segregation Distorter in Drosophila melanogaster.
Greenberg Temin R. Greenberg Temin R. Genetics. 2020 Aug;215(4):1085-1105. doi: 10.1534/genetics.120.303150. Epub 2020 Jun 19. Genetics. 2020. PMID: 32561521 Free PMC article. - A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis.
Sharma J, Antenos M, Madan P. Sharma J, et al. Genes (Basel). 2021 Feb 16;12(2):281. doi: 10.3390/genes12020281. Genes (Basel). 2021. PMID: 33669396 Free PMC article. Review. - A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia.
Kee HL, Dishinger JF, Blasius TL, Liu CJ, Margolis B, Verhey KJ. Kee HL, et al. Nat Cell Biol. 2012 Mar 4;14(4):431-7. doi: 10.1038/ncb2450. Nat Cell Biol. 2012. PMID: 22388888 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases