A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis - PubMed (original) (raw)
A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis
J Malsam et al. FEBS Lett. 1999.
Free article
Abstract
ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365-1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPgammaS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081-3090), a non-hydrolyzable analogue of GTP. We now demonstrate that the GTPase involved in the regulation of cargo uptake is ARF, revealing a multi-functional role of this GTPase in COPI-mediated vesicular transport. The molecular mechanism of cargo uptake as well as the functional implications of these findings on the overall process of COPI vesicle biogenesis are discussed.
Similar articles
- Functional reconstitution of COPI coat assembly and disassembly using chemically defined components.
Reinhard C, Schweikert M, Wieland FT, Nickel W. Reinhard C, et al. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8253-7. doi: 10.1073/pnas.1432391100. Epub 2003 Jun 27. Proc Natl Acad Sci U S A. 2003. PMID: 12832619 Free PMC article. - COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo.
Pepperkok R, Whitney JA, Gomez M, Kreis TE. Pepperkok R, et al. J Cell Sci. 2000 Jan;113 ( Pt 1):135-44. doi: 10.1242/jcs.113.1.135. J Cell Sci. 2000. PMID: 10591632 - Uptake by COPI-coated vesicles of both anterograde and retrograde cargo is inhibited by GTPgammaS in vitro.
Nickel W, Malsam J, Gorgas K, Ravazzola M, Jenne N, Helms JB, Wieland FT. Nickel W, et al. J Cell Sci. 1998 Oct;111 ( Pt 20):3081-90. doi: 10.1242/jcs.111.20.3081. J Cell Sci. 1998. PMID: 9739081 - The COPI system: molecular mechanisms and function.
Beck R, Rawet M, Wieland FT, Cassel D. Beck R, et al. FEBS Lett. 2009 Sep 3;583(17):2701-9. doi: 10.1016/j.febslet.2009.07.032. Epub 2009 Jul 22. FEBS Lett. 2009. PMID: 19631211 Review. - The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants.
Memon AR. Memon AR. Biochim Biophys Acta. 2004 Jul 1;1664(1):9-30. doi: 10.1016/j.bbamem.2004.04.005. Biochim Biophys Acta. 2004. PMID: 15238254 Review.
Cited by
- ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the Golgi membrane of living cells.
Kartberg F, Asp L, Dejgaard SY, Smedh M, Fernandez-Rodriguez J, Nilsson T, Presley JF. Kartberg F, et al. J Biol Chem. 2010 Nov 19;285(47):36709-20. doi: 10.1074/jbc.M110.180380. Epub 2010 Sep 21. J Biol Chem. 2010. PMID: 20858901 Free PMC article. - Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.
DeRegis CJ, Rahl PB, Hoffman GR, Cerione RA, Collins RN. DeRegis CJ, et al. BMC Cell Biol. 2008 Jan 22;9:3. doi: 10.1186/1471-2121-9-3. BMC Cell Biol. 2008. PMID: 18211691 Free PMC article. - ARFGAP1 is dynamically associated with lipid droplets in hepatocytes.
Gannon J, Fernandez-Rodriguez J, Alamri H, Feng SB, Kalantari F, Negi S, Wong AH, Mazur A, Asp L, Fazel A, Salman A, Lazaris A, Metrakos P, Bergeron JJ, Nilsson T. Gannon J, et al. PLoS One. 2014 Nov 14;9(11):e111309. doi: 10.1371/journal.pone.0111309. eCollection 2014. PLoS One. 2014. PMID: 25397679 Free PMC article. - Oligomerization and dissociation of AP-1 adaptors are regulated by cargo signals and by ArfGAP1-induced GTP hydrolysis.
Meyer DM, Crottet P, Maco B, Degtyar E, Cassel D, Spiess M. Meyer DM, et al. Mol Biol Cell. 2005 Oct;16(10):4745-54. doi: 10.1091/mbc.e05-06-0568. Epub 2005 Aug 10. Mol Biol Cell. 2005. PMID: 16093346 Free PMC article. - Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1.
Lanoix J, Ouwendijk J, Stark A, Szafer E, Cassel D, Dejgaard K, Weiss M, Nilsson T. Lanoix J, et al. J Cell Biol. 2001 Dec 24;155(7):1199-212. doi: 10.1083/jcb.200108017. Epub 2001 Dec 17. J Cell Biol. 2001. PMID: 11748249 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources