A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter - PubMed (original) (raw)

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A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter

L A Pereira et al. Nucleic Acids Res. 2000.

Abstract

The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA-protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions. It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.

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Figures

Figure 1

Structure of the HIV-1 5′-LTR and gag leader sequence (GLS). The U3 region contains basal, enhancer and modulatory promoter elements, including the negative regulatory element (NRE). The sequence of the transactivating region (TAR) is found in the repeat (R) region. The tRNA primer binding (tRNA) and major splice donor (SD) sites are within the GLS. The initiation codon of the gag gene is depicted by AUG. Numbering above the boxed regions starts from the first nucleotide of the proviral DNA sequence (here using the HIV-1HXB2 sequence; accession no. K03455), numbering below the boxed regions is relative to the transcription start site nucleotide +1.

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A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter - PubMed (original) (raw)