Regulating actin-filament dynamics in vivo - PubMed (original) (raw)
Review
Regulating actin-filament dynamics in vivo
H Chen et al. Trends Biochem Sci. 2000 Jan.
Abstract
The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.