High-resolution mapping of iso-orientation columns by fMRI - PubMed (original) (raw)
High-resolution mapping of iso-orientation columns by fMRI
D S Kim et al. Nat Neurosci. 2000 Feb.
Abstract
Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map cortical columnar structures is highly controversial, as the ultimate functional specificity of BOLD remains unknown. Here we report a biphasic BOLD response to visual stimulation in the primary visual cortex of cats. In functional imaging, the initial BOLD signal decrease accurately labeled individual iso-orientation columns. In contrast, the delayed positive BOLD changes indicated the pattern of overall activation in the visual cortex, but were less suited to discriminate active from inactive columns.
Comment in
- Non-invasive visualization of cortical columns by fMRI.
Grinvald A, Slovin H, Vanzetta I. Grinvald A, et al. Nat Neurosci. 2000 Feb;3(2):105-7. doi: 10.1038/72045. Nat Neurosci. 2000. PMID: 10649563 No abstract available. - Can current fMRI techniques reveal the micro-architecture of cortex?
Logothetis N. Logothetis N. Nat Neurosci. 2000 May;3(5):413-4. doi: 10.1038/74768. Nat Neurosci. 2000. PMID: 10769371 No abstract available.
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