Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity - PubMed (original) (raw)
Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
S Ashkar et al. Science. 2000.
Abstract
Cell-mediated (type-1) immunity is necessary for immune protection against most intracellular pathogens and, when excessive, can mediate organ-specific autoimmune destruction. Mice deficient in Eta-1 (also called osteopontin) gene expression have severely impaired type-1 immunity to viral infection [herpes simplex virus-type 1 (KOS strain)] and bacterial infection (Listeria monocytogenes) and do not develop sarcoid-type granulomas. Interleukin-12 (IL-12) and interferon-gamma production is diminished, and IL-10 production is increased. A phosphorylation-dependent interaction between the amino-terminal portion of Eta-1 and its integrin receptor stimulated IL-12 expression, whereas a phosphorylation-independent interaction with CD44 inhibited IL-10 expression. These findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression.
Similar articles
- Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infection.
Bauer D, Schmitz A, Van Rooijen N, Steuhl KP, Heiligenhaus A. Bauer D, et al. Immunology. 2002 Sep;107(1):118-28. doi: 10.1046/j.1365-2567.2002.01477.x. Immunology. 2002. PMID: 12225370 Free PMC article. - Osteopontin is not required for the development of Th1 responses and viral immunity.
Abel B, Freigang S, Bachmann MF, Boschert U, Kopf M. Abel B, et al. J Immunol. 2005 Nov 1;175(9):6006-13. doi: 10.4049/jimmunol.175.9.6006. J Immunol. 2005. PMID: 16237095 - Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice.
Humann J, Bjordahl R, Andreasen K, Lenz LL. Humann J, et al. J Immunol. 2007 Feb 15;178(4):2407-14. doi: 10.4049/jimmunol.178.4.2407. J Immunol. 2007. PMID: 17277147 - The immunology of Eta-1/osteopontin.
Weber GF, Cantor H. Weber GF, et al. Cytokine Growth Factor Rev. 1996 Oct;7(3):241-8. doi: 10.1016/s1359-6101(96)00030-5. Cytokine Growth Factor Rev. 1996. PMID: 8971479 Review. - Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis.
Mielke ME, Peters C, Hahn H. Mielke ME, et al. Immunol Rev. 1997 Aug;158:79-93. doi: 10.1111/j.1600-065x.1997.tb00994.x. Immunol Rev. 1997. PMID: 9314076 Review.
Cited by
- Dynamics of osteopontin levels and correlation with parasitemia in acute malaria in Uganda and Sweden.
Mortazavi SE, Lugaajju A, Danielsson L, Wu B, Norrgren H, Persson KEM. Mortazavi SE, et al. BMC Infect Dis. 2024 Oct 15;24(1):1164. doi: 10.1186/s12879-024-10076-x. BMC Infect Dis. 2024. PMID: 39407132 - Fisetin reduces ovalbumin-triggered airway remodeling by preventing phenotypic switching of airway smooth muscle cells.
Liu Y, Yin Q, Liu B, Lu Z, Liu M, Meng L, He C, Chang J. Liu Y, et al. Respir Res. 2024 Oct 14;25(1):370. doi: 10.1186/s12931-024-03005-8. Respir Res. 2024. PMID: 39402516 Free PMC article. - Inflammation and Elevated Osteopontin in Plasma and CSF in Cerebral Malaria Compared to _Plasmodium_-Negative Neurological Infections.
Stins MF, Mtaja A, Mulendele E, Mwimbe D, Pinilla-Monsalve GD, Mutengo M, Pardo CA, Chipeta J. Stins MF, et al. Int J Mol Sci. 2024 Sep 5;25(17):9620. doi: 10.3390/ijms25179620. Int J Mol Sci. 2024. PMID: 39273566 Free PMC article. - Adipokines and their role in acute pancreatitis.
Rafaqat S, Radoman-Vujačić I, Patoulias D, Khurshid H, Klisić A. Rafaqat S, et al. J Med Biochem. 2024 Jun 15;43(4):512-527. doi: 10.5937/jomb0-47515. J Med Biochem. 2024. PMID: 39139157 Free PMC article. - Role of sex as a biological variable in neonatal alveolar macrophages.
Leek C, Cantu A, Sonti S, Gutierrez MC, Eldredge L, Sajti E, Xu HN, Lingappan K. Leek C, et al. Redox Biol. 2024 Sep;75:103296. doi: 10.1016/j.redox.2024.103296. Epub 2024 Aug 2. Redox Biol. 2024. PMID: 39098263 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous