Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate - PubMed (original) (raw)
Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate
M F Mehler et al. Dev Neurosci. 2000.
Abstract
Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones of the brain throughout embryonic, postnatal and adult life, the different neural cell types are generated within discrete temporospatial developmental windows. This might suggest that multipotent progenitor cells encounter different signals during each developmental stage, thus accounting for separate waves of lineage commitment and cellular differentiation. This study demonstrates, however, that progenitor cell responses to the same class of signals, the bone morphogenetic proteins (BMPs), change during ontogeny, and that these same signals may thus initiate progenitor cell elaboration of several different lineages. BMPs promote cell death and inhibit the proliferation of early (embryonic day 13, E13) ventricular zone progenitor cells. At later embryonic (E16) stages of cerebral cortical development, BMPs exhibit a concentration-dependent dissociation of cellular actions, with either enhancement of neuronal and astroglial elaboration (at 1-10 ng/ml) or potentiation of cell death (at 100 ng/ml). Finally, during the period of perinatal cortical gliogenesis, BMPs enhance astroglial lineage elaboration. By contrast, oligodendroglial lineage elaboration is inhibited by the BMPs at all stages. Further, application of the BMP antagonist noggin to cultured progenitors promotes the generation of oligodendrocytes, indicating that endogenous BMP signaling can actively suppress oligodendrogliogenesis. These observations suggest that developmental changes in neural progenitor cell responsiveness to the BMPs may represent a novel mechanism for orchestrating context-specific cellular events such as lineage elaboration and cellular viability.
Copyright 2000 S. Karger AG, Basel.
Similar articles
- Developmental changes in progenitor cell responsiveness to cytokines.
Zhu G, Mehler MF, Mabie PC, Kessler JA. Zhu G, et al. J Neurosci Res. 1999 Apr 15;56(2):131-45. doi: 10.1002/(sici)1097-4547(19990415)56:2<131::aid-jnr3>3.0.co;2-i. J Neurosci Res. 1999. PMID: 10494102 - Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype.
Mabie PC, Mehler MF, Kessler JA. Mabie PC, et al. J Neurosci. 1999 Aug 15;19(16):7077-88. doi: 10.1523/JNEUROSCI.19-16-07077.1999. J Neurosci. 1999. PMID: 10436062 Free PMC article. - Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells.
Zhu G, Mehler MF, Zhao J, Yu Yung S, Kessler JA. Zhu G, et al. Dev Biol. 1999 Nov 1;215(1):118-29. doi: 10.1006/dbio.1999.9431. Dev Biol. 1999. PMID: 10525354 - Postnatal cerebral cortical multipotent progenitors: regulatory mechanisms and potential role in the development of novel neural regenerative strategies.
Mehler MF, Gokhan S. Mehler MF, et al. Brain Pathol. 1999 Jul;9(3):515-26. doi: 10.1111/j.1750-3639.1999.tb00539.x. Brain Pathol. 1999. PMID: 10416991 Free PMC article. Review. - Mechanisms regulating lineage diversity during mammalian cerebral cortical neurogenesis and gliogenesis.
Mehler MF. Mehler MF. Results Probl Cell Differ. 2002;39:27-52. doi: 10.1007/978-3-540-46006-0_2. Results Probl Cell Differ. 2002. PMID: 12357985 Review.
Cited by
- NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade.
Kendall SE, Battelli C, Irwin S, Mitchell JG, Glackin CA, Verdi JM. Kendall SE, et al. Mol Cell Biol. 2005 Sep;25(17):7711-24. doi: 10.1128/MCB.25.17.7711-7724.2005. Mol Cell Biol. 2005. PMID: 16107717 Free PMC article. - The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis.
Annenkov A. Annenkov A. Mol Neurobiol. 2009 Dec;40(3):195-215. doi: 10.1007/s12035-009-8081-0. Epub 2009 Aug 29. Mol Neurobiol. 2009. PMID: 19714501 Review. - Intrinsic and extrinsic regulation of the proliferation and differentiation of cells in the rodent rostral migratory stream.
Coskun V, Luskin MB. Coskun V, et al. J Neurosci Res. 2002 Sep 15;69(6):795-802. doi: 10.1002/jnr.10336. J Neurosci Res. 2002. PMID: 12205673 Free PMC article. Review. - Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation.
Abrajano JJ, Qureshi IA, Gokhan S, Zheng D, Bergman A, Mehler MF. Abrajano JJ, et al. PLoS One. 2009 Nov 3;4(11):e7665. doi: 10.1371/journal.pone.0007665. PLoS One. 2009. PMID: 19888342 Free PMC article. - Secretome analysis of human oligodendrocytes derived from neural stem cells.
Kim WK, Kim D, Cui J, Jang HH, Kim KS, Lee HJ, Kim SU, Ahn SM. Kim WK, et al. PLoS One. 2014 Jan 2;9(1):e84292. doi: 10.1371/journal.pone.0084292. eCollection 2014. PLoS One. 2014. PMID: 24392122 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical