The induction of tolerance by dendritic cells that have captured apoptotic cells - PubMed (original) (raw)

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The induction of tolerance by dendritic cells that have captured apoptotic cells

R M Steinman et al. J Exp Med. 2000.

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Figure 1

Figure 1

An illustration of the self-nonself problem from the perspective of DCs. During influenza infection of the airway, a site rich in DCs (reference 59), there is extensive apoptotic death of infected airway epithelial cells, which the DCs would likely process simultaneously with the influenza virus (references 29, 30).

Figure 3

Figure 3

Pathways whereby DCs might induce peripheral tolerance to antigens within tissue cells undergoing normal cell turnover by apoptosis. DC precursors traffic through tissues, phagocytose dying cells or apoptotic bodies, and then enter the lymph. Upon reaching the lymph node, the DCs tolerize naive, self-reactive T cells either directly, or indirectly (as diagrammed here) after reprocessing by different regulatory or tolerogenic DCs in the lymph node.

Figure 2

Figure 2

Diagram of the model of Kurts et al. (references 34, 35). Self-peptides in tissue cells, here the insulin-producing β cells of the pancreatic islets, are presented in a tolerogenic way by bone marrow–derived cells in the draining pancreatic lymph nodes.

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