NF-kappaB and the innate immune response - PubMed (original) (raw)

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NF-kappaB and the innate immune response

E N Hatada et al. Curr Opin Immunol. 2000 Feb.

Abstract

In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappaB (NFkappaB). NF-kappaB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappaB have been clarified by gene inactivation and biochemical analysis.

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