Cellular routes of invasion by enteropathogens - PubMed (original) (raw)
Review
Cellular routes of invasion by enteropathogens
A Vazquez-Torres et al. Curr Opin Microbiol. 2000 Feb.
Abstract
The cellular pathways of infection utilized by pathogenic enteric bacteria have important implications for their clinical manifestations. Yersinia reaches Peyer's patches via M cells and uses plasmid-encoded factors to resist phagocytic cells. Shigella also translocates via M cells and incapacitates phagocytes, but subsequently re-enters the epithelium basolaterally to elicit an acute inflammatory response. Salmonella has recently been shown to both colonize Peyer's patches via M cells and independently disseminate to extraintestinal sites via CD18-expressing phagocytes. M cell-mediated entry can lead to gastroenteritis and mucosal antibody production, while systemic dissemination can result in septicemia and elicitation of systemic immune responses.
Similar articles
- Intestinal M cells and their role in bacterial infection.
Clark MA, Jepson MA. Clark MA, et al. Int J Med Microbiol. 2003 Apr;293(1):17-39. doi: 10.1078/1438-4221-00242. Int J Med Microbiol. 2003. PMID: 12755364 Review. - The role of M cells in Salmonella infection.
Jepson MA, Clark MA. Jepson MA, et al. Microbes Infect. 2001 Nov-Dec;3(14-15):1183-90. doi: 10.1016/s1286-4579(01)01478-2. Microbes Infect. 2001. PMID: 11755406 Review. - Application of a mouse ligated Peyer’s patch intestinal loop assay to evaluate bacterial uptake by M cells.
Fukuda S, Hase K, Ohno H. Fukuda S, et al. J Vis Exp. 2011 Dec 17;(58):3225. doi: 10.3791/3225. J Vis Exp. 2011. PMID: 22215009 Free PMC article. - Border patrols and secret passageways across the intestinal epithelium.
Isberg RR, Barnes P. Isberg RR, et al. Trends Microbiol. 2000 Jul;8(7):291-3. doi: 10.1016/s0966-842x(00)01785-6. Trends Microbiol. 2000. PMID: 10878756 No abstract available. - Peyer's patch-deficient mice demonstrate that Mycobacterium avium subsp. paratuberculosis translocates across the mucosal barrier via both M cells and enterocytes but has inefficient dissemination.
Bermudez LE, Petrofsky M, Sommer S, Barletta RG. Bermudez LE, et al. Infect Immun. 2010 Aug;78(8):3570-7. doi: 10.1128/IAI.01411-09. Epub 2010 May 24. Infect Immun. 2010. PMID: 20498259 Free PMC article.
Cited by
- _Bacillus_-Based Direct-Fed Microbial Reduces the Pathogenic Synergy of a Coinfection with Salmonella enterica Serovar Choleraesuis and Porcine Reproductive and Respiratory Syndrome Virus.
Zuckermann FA, Husmann R, Chen W, Roady P, Pfeiff J, Leistikow KR, Duersteler M, Son S, King MR, Augspurger NR. Zuckermann FA, et al. Infect Immun. 2022 Apr 21;90(4):e0057421. doi: 10.1128/iai.00574-21. Epub 2022 Mar 7. Infect Immun. 2022. PMID: 35254092 Free PMC article. - Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells.
Götz A, Eylert E, Eisenreich W, Goebel W. Götz A, et al. PLoS One. 2010 May 11;5(5):e10586. doi: 10.1371/journal.pone.0010586. PLoS One. 2010. PMID: 20485672 Free PMC article. - Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host.
Naylor SW, Low JC, Besser TE, Mahajan A, Gunn GJ, Pearce MC, McKendrick IJ, Smith DG, Gally DL. Naylor SW, et al. Infect Immun. 2003 Mar;71(3):1505-12. doi: 10.1128/IAI.71.3.1505-1512.2003. Infect Immun. 2003. PMID: 12595469 Free PMC article. - Diverse secreted effectors are required for Salmonella persistence in a mouse infection model.
Kidwai AS, Mushamiri I, Niemann GS, Brown RN, Adkins JN, Heffron F. Kidwai AS, et al. PLoS One. 2013 Aug 12;8(8):e70753. doi: 10.1371/journal.pone.0070753. eCollection 2013. PLoS One. 2013. PMID: 23950998 Free PMC article. - Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo.
Westphal S, Lügering A, von Wedel J, von Eiff C, Maaser C, Spahn T, Heusipp G, Schmidt MA, Herbst H, Williams IR, Domschke W, Kucharzik T. Westphal S, et al. Am J Pathol. 2008 Mar;172(3):671-80. doi: 10.2353/ajpath.2008.070393. Epub 2008 Feb 7. Am J Pathol. 2008. PMID: 18258848 Free PMC article.