Active killing of neurons during development and following stress: a role for p75(NTR) and Fas? - PubMed (original) (raw)

Review

Active killing of neurons during development and following stress: a role for p75(NTR) and Fas?

C Raoul et al. Curr Opin Neurobiol. 2000 Feb.

Abstract

Evidence for active triggering of neuronal death continues to accumulate. The transmembrane receptors p75(NTR) and Fas can trigger (and in some cases are required for) programmed cell death of the neurons that express them, through signalling pathways that are regulated by a variety of cytoplasmic effectors. Neuronal death induced by trophic deprivation often requires Fas signalling, further blurring the boundaries between naturally occurring and stress-induced neuronal death.

PubMed Disclaimer

Similar articles

• Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS.
  Tanaka K, Kelly CE, Goh KY, Lim KB, Ibáñez CF. Tanaka K, et al. J Neurosci. 2016 May 18;36(20):5587-95. doi: 10.1523/JNEUROSCI.4536-15.2016. J Neurosci. 2016. PMID: 27194337 Free PMC article.
• Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.
  Kendall SE, Goldhawk DE, Kubu C, Barker PA, Verdi JM. Kendall SE, et al. Mech Dev. 2002 Sep;117(1-2):187-200. doi: 10.1016/s0925-4773(02)00204-6. Mech Dev. 2002. PMID: 12204258
• p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
  Bai Y, Li Q, Yang J, Zhou X, Yin X, Zhao D. Bai Y, et al. Neurosci Res. 2008 Sep;62(1):9-14. doi: 10.1016/j.neures.2008.05.004. Epub 2008 May 23. Neurosci Res. 2008. PMID: 18602709
• Neurotrophins and their receptors: a convergence point for many signalling pathways.
  Chao MV. Chao MV. Nat Rev Neurosci. 2003 Apr;4(4):299-309. doi: 10.1038/nrn1078. Nat Rev Neurosci. 2003. PMID: 12671646 Review. No abstract available.

Cited by

• ERK-mediated activation of Fas apoptotic inhibitory molecule 2 (Faim2) prevents apoptosis of 661W cells in a model of detachment-induced photoreceptor cell death.
  Besirli CG, Zheng QD, Reed DM, Zacks DN. Besirli CG, et al. PLoS One. 2012;7(9):e46664. doi: 10.1371/journal.pone.0046664. Epub 2012 Sep 28. PLoS One. 2012. PMID: 23029562 Free PMC article.
• Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.
  Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R. Mahul-Mellier AL, et al. J Biol Chem. 2008 Dec 12;283(50):34954-65. doi: 10.1074/jbc.M803140200. Epub 2008 Oct 20. J Biol Chem. 2008. PMID: 18936101 Free PMC article.
• Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway.
  Lee MS, Chao J, Yen JC, Lin LW, Tsai FS, Hsieh MT, Peng WH, Cheng HY. Lee MS, et al. Molecules. 2012 Dec 27;18(1):354-72. doi: 10.3390/molecules18010354. Molecules. 2012. PMID: 23271470 Free PMC article.
• Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells.
  Choi AO, Cho SJ, Desbarats J, Lovrić J, Maysinger D. Choi AO, et al. J Nanobiotechnology. 2007 Feb 12;5:1. doi: 10.1186/1477-3155-5-1. J Nanobiotechnology. 2007. PMID: 17295922 Free PMC article.
• Pathophysiology and neuroprotection of global and focal perinatal brain injury: lessons from animal models.
  Titomanlio L, Fernández-López D, Manganozzi L, Moretti R, Vexler ZS, Gressens P. Titomanlio L, et al. Pediatr Neurol. 2015 Jun;52(6):566-584. doi: 10.1016/j.pediatrneurol.2015.01.016. Epub 2015 Jan 31. Pediatr Neurol. 2015. PMID: 26002050 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal