Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells - PubMed (original) (raw)
Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells
M Ozaki et al. J Neurosci Res. 2000.
Abstract
Neuregulins (NRGs), a large group of structurally related signaling proteins, are likely to have important roles in the development, maintenance and repair of the nervous system and other selected tissues. We have demonstrated, by using the major form of NRG cloned from the mouse cerebellum that both the soluble form and the membrane anchored form of NRG may serve different functions in synaptogenesis. The soluble form of NRG was produced by proteolytic cleavage of the membrane anchored form of NRG. The proteolytic cleavage was promoted by protein kinase activation. The cleaved form of NRG trans-synaptically regulated the expression of the NMDA (N-methyl-D-aspartate) receptor subunit NR2C as neurally-derived factors, whereas the membrane anchored form of NRG showed a homophilic binding activity between NRGbeta1s. In adult mice the membrane anchored form of NRG was concentrated in neuro-terminals of both granule cells and pontocerebellar mossy fibers. The fact that NRG can be functionally viewed as cell recognition molecules as well as neurotrophic agents suggests new possibilities for the important class of molecules.
Copyright 2000 Wiley-Liss, Inc.
Similar articles
- Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo.
Gajendran N, Kapfhammer JP, Lain E, Canepari M, Vogt K, Wisden W, Brenner HR. Gajendran N, et al. J Neurosci. 2009 Feb 25;29(8):2404-13. doi: 10.1523/JNEUROSCI.4303-08.2009. J Neurosci. 2009. PMID: 19244516 Free PMC article. - Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.
Rieff HI, Raetzman LT, Sapp DW, Yeh HH, Siegel RE, Corfas G. Rieff HI, et al. J Neurosci. 1999 Dec 15;19(24):10757-66. doi: 10.1523/JNEUROSCI.19-24-10757.1999. J Neurosci. 1999. PMID: 10594059 Free PMC article. - Neuregulin-beta induces expression of an NMDA-receptor subunit.
Ozaki M, Sasner M, Yano R, Lu HS, Buonanno A. Ozaki M, et al. Nature. 1997 Dec 18-25;390(6661):691-4. doi: 10.1038/37795. Nature. 1997. PMID: 9414162 - Neuregulin signaling via erbB receptor assemblies in the nervous system.
Murphy S, Krainock R, Tham M. Murphy S, et al. Mol Neurobiol. 2002 Feb;25(1):67-77. doi: 10.1385/MN:25:1:067. Mol Neurobiol. 2002. PMID: 11890458 Review. - Neuregulins: primary or secondary signals for the control of synapse-specific gene expression.
Rimer M. Rimer M. J Neurocytol. 2003 Jun-Sep;32(5-8):665-75. doi: 10.1023/B:NEUR.0000020615.79831.51. J Neurocytol. 2003. PMID: 15034259 Review.
Cited by
- Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development.
Boxy P, Nykjær A, Kisiswa L. Boxy P, et al. Front Mol Neurosci. 2023 May 12;16:1181397. doi: 10.3389/fnmol.2023.1181397. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37251644 Free PMC article. Review. - Plasma neuregulin 1 as a synaptic biomarker in Alzheimer's disease: a discovery cohort study.
Vrillon A, Mouton-Liger F, Martinet M, Cognat E, Hourregue C, Dumurgier J, Bouaziz-Amar E, Brinkmalm A, Blennow K, Zetterberg H, Hugon J, Paquet C. Vrillon A, et al. Alzheimers Res Ther. 2022 May 23;14(1):71. doi: 10.1186/s13195-022-01014-7. Alzheimers Res Ther. 2022. PMID: 35606871 Free PMC article. - The Long Journey of Pontine Nuclei Neurons: From Rhombic Lip to Cortico-Ponto-Cerebellar Circuitry.
Kratochwil CF, Maheshwari U, Rijli FM. Kratochwil CF, et al. Front Neural Circuits. 2017 May 17;11:33. doi: 10.3389/fncir.2017.00033. eCollection 2017. Front Neural Circuits. 2017. PMID: 28567005 Free PMC article. Review. - Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.
Gao R, Penzes P. Gao R, et al. Curr Mol Med. 2015;15(2):146-67. doi: 10.2174/1566524015666150303003028. Curr Mol Med. 2015. PMID: 25732149 Free PMC article. Review. - Phenotypic characterization of transgenic mice overexpressing neuregulin-1.
Kato T, Kasai A, Mizuno M, Fengyi L, Shintani N, Maeda S, Yokoyama M, Ozaki M, Nawa H. Kato T, et al. PLoS One. 2010 Dec 9;5(12):e14185. doi: 10.1371/journal.pone.0014185. PLoS One. 2010. PMID: 21151609 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases