Translating stem and progenitor cell biology to the clinic: barriers and opportunities - PubMed (original) (raw)
Review
Translating stem and progenitor cell biology to the clinic: barriers and opportunities
I L Weissman. Science. 2000.
Abstract
Stem cells are the natural units of embryonic generation, and also adult regeneration, of a variety of tissues. Recently, the list of tissues that use the model of differentiation from stem to progenitor to mature cell has increased from blood to include a variety of tissues, including both central and peripheral nervous systems and skeletal muscle; it is also possible that all organs and tissues are derived from, and still contain, stem cells. Because the number and activities of stem cells and their progeny are homeostatically regulated, clinical stem cell transplantation could greatly add to the physician's armamentarium against degenerative diseases.
Similar articles
- Hematopoietic stem and progenitor cells and the inflammatory response.
Jaiswal S, Weissman IL. Jaiswal S, et al. Ann N Y Acad Sci. 2009 Sep;1174:118-21. doi: 10.1111/j.1749-6632.2009.04930.x. Ann N Y Acad Sci. 2009. PMID: 19769744 - Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system.
Shizuru JA, Negrin RS, Weissman IL. Shizuru JA, et al. Annu Rev Med. 2005;56:509-38. doi: 10.1146/annurev.med.54.101601.152334. Annu Rev Med. 2005. PMID: 15660525 Review. - [Adult stem cells. Prospects for the therapy].
Reis HE. Reis HE. Med Klin (Munich). 2003 Dec 15;98 Suppl 2:2-3. Med Klin (Munich). 2003. PMID: 14974706 German. No abstract available. - Myocardial regeneration with bone-marrow-derived stem cells.
Yoon YS, Lee N, Scadova H. Yoon YS, et al. Biol Cell. 2005 Apr;97(4):253-63. doi: 10.1042/BC20040099. Biol Cell. 2005. PMID: 15762847 Review. - A new concept of stem cell disorders and their new therapy.
Ikehara S. Ikehara S. J Hematother Stem Cell Res. 2003 Dec;12(6):643-53. doi: 10.1089/15258160360732678. J Hematother Stem Cell Res. 2003. PMID: 14977474 Review.
Cited by
- Breast milk stem cells: Are they magic bullets in neonatology?
Kersin SG, Özek E. Kersin SG, et al. Turk Arch Pediatr. 2021 May 1;56(3):187-191. doi: 10.5152/TurkArchPediatr.2021.21006. eCollection 2021. Turk Arch Pediatr. 2021. PMID: 34104907 Free PMC article. Review. - Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination.
Zarini D, Pasbakhsh P, Shabani M, Mojaverrostami S, Hashemi M, Amirizadeh S, Majidpoor J, Omidi A, Mortezaee K, Kashani IR. Zarini D, et al. Neurotox Res. 2022 Oct;40(5):1415-1426. doi: 10.1007/s12640-022-00556-w. Epub 2022 Sep 2. Neurotox Res. 2022. PMID: 36053462 - Identification and expansion of pancreatic stem/progenitor cells.
Zhang YQ, Kritzik M, Sarvetnick N. Zhang YQ, et al. J Cell Mol Med. 2005 Apr-Jun;9(2):331-44. doi: 10.1111/j.1582-4934.2005.tb00359.x. J Cell Mol Med. 2005. PMID: 15963253 Free PMC article. Review. - Current status of stem cell treatments and innovative approaches for stress urinary incontinence.
Seval MM, Koyuncu K. Seval MM, et al. Front Med (Lausanne). 2022 Dec 2;9:1073758. doi: 10.3389/fmed.2022.1073758. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36530893 Free PMC article. Review. - Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs.
Kozakowska M, Szade K, Dulak J, Jozkowicz A. Kozakowska M, et al. Antioxid Redox Signal. 2014 Apr 10;20(11):1827-50. doi: 10.1089/ars.2013.5341. Epub 2014 Jan 30. Antioxid Redox Signal. 2014. PMID: 24053682 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical