Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance - PubMed (original) (raw)

Comparative Study

. 2000 Feb 25;287(5457):1479-82.

doi: 10.1126/science.287.5457.1479.

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Comparative Study

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

J Björkman et al. Science. 2000.

Abstract

Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.

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