Alpha-synuclein overexpression promotes aggregation of mutant huntingtin - PubMed (original) (raw)

. 2000 Mar 15;346 Pt 3(Pt 3):577-81.

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• PMID: 10698681
• PMCID: PMC1220887

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin

R A Furlong et al. Biochem J. 2000.

Abstract

Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-transfected with EGFP-huntingtin-(CAG)(72) and alpha-synuclein, a major component of Parkinson's disease aggregates. However, alpha-synuclein does not form aggregates by itself, nor does it appear in huntingtin inclusions in vitro.

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