Tolerating the nervous system: a delicate balance - PubMed (original) (raw)
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Tolerating the nervous system: a delicate balance
E S Huseby et al. J Exp Med. 2000.
No abstract available
Figures
Figure 1
Autoreactive T cells that are not eliminated or rendered unresponsive by tolerance mechanisms normally remain quiescent in the periphery. Priming events that trigger their differentiation into effector T cells can initiate autoimmune responses. The function of regulatory T cells is to inhibit these responses and prevent autoimmunity.
Comment on
- High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.
Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. Anderson AC, et al. J Exp Med. 2000 Mar 6;191(5):761-70. doi: 10.1084/jem.191.5.761. J Exp Med. 2000. PMID: 10704458 Free PMC article.
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