Heat shock proteins refine the danger theory - PubMed (original) (raw)

Heat shock proteins refine the danger theory

S M Todryk et al. Immunology. 2000 Mar.

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Figure 1

Figure 1

Summary of immune reactions to ‘dangerous’ and ‘quiet’ cell death. Cells dying by apoptotic, ‘quiet’ cell death are scavenged by macrophages. Peptides are presented in the absence of costimulation and T cells die or are anergized. Cells dying in ‘dangerous’ situations, induced by tissue damage/stress (physical/chemical), viral infection or inflammation (leading to necrotic cell death), cause danger signal upregulation and/or release, and cell lysis. DC are recruited in numbers and efficiently take up antigens, especially antigens chaperoned by hsp. DC mature and migrate to lymph nodes where they present peptides to T cells with co-stimulation. T cells primed/activated in numbers can feed back and kill tumour cells.

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