Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress - PubMed (original) (raw)

. 2000 Mar 17;275(11):7470-3.

doi: 10.1074/jbc.275.11.7470.

Affiliations

• PMID: 10713049
• DOI: 10.1074/jbc.275.11.7470

Free article

Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress

X Sun et al. J Biol Chem. 2000.

Free article

Abstract

Protein kinase C (PKC) isoforms are phosphorylated on tyrosine in the response of cells to oxidative stress. The present studies demonstrate that treatment of cells with hydrogen peroxide (H(2)O(2)) induces binding of the PKCdelta isoform and the c-Abl protein-tyrosine kinase. The results show that c-Abl phosphorylates PKCdelta in the H(2)O(2) response. We also show that PKCdelta phosphorylates and activates c-Abl in vitro. In cells, induction of c-Abl activity by H(2)O(2) is attenuated by the PKCdelta inhibitor, rottlerin, and by overexpression of the regulatory domain of PKCdelta. These findings support a functional interaction between PKCdelta and c-Abl in the cellular response to oxidative stress.

PubMed Disclaimer

Similar articles

• Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation.
  Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D. Yuan ZM, et al. Oncogene. 1998 Apr 2;16(13):1643-8. doi: 10.1038/sj.onc.1201698. Oncogene. 1998. PMID: 9582011
• Targeting of protein kinase C delta to mitochondria in the oxidative stress response.
  Majumder PK, Mishra NC, Sun X, Bharti A, Kharbanda S, Saxena S, Kufe D. Majumder PK, et al. Cell Growth Differ. 2001 Sep;12(9):465-70. Cell Growth Differ. 2001. PMID: 11571229
• Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress.
  Kumar S, Bharti A, Mishra NC, Raina D, Kharbanda S, Saxena S, Kufe D. Kumar S, et al. J Biol Chem. 2001 May 18;276(20):17281-5. doi: 10.1074/jbc.M101414200. Epub 2001 Feb 28. J Biol Chem. 2001. PMID: 11350980
• Regulation of cell apoptosis by protein kinase c delta.
  Brodie C, Blumberg PM. Brodie C, et al. Apoptosis. 2003 Jan;8(1):19-27. doi: 10.1023/a:1021640817208. Apoptosis. 2003. PMID: 12510148 Review.
• Determination of cell fate by c-Abl activation in the response to DNA damage.
  Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Kharbanda S, et al. Oncogene. 1998 Dec 24;17(25):3309-18. doi: 10.1038/sj.onc.1202571. Oncogene. 1998. PMID: 9916993 Review.

Cited by

• BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori.
  Qin S, Sun L, Zhang S, Sun X, Li M. Qin S, et al. Insects. 2022 Oct 22;13(11):967. doi: 10.3390/insects13110967. Insects. 2022. PMID: 36354792 Free PMC article.
• Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance.
  Dong Q, Li D, Zhao H, Zhang X, Liu Y, Hu Y, Yao Y, Zhu L, Wang GF, Liu H, Gao T, Niu X, Zheng T, Song C, Wang D, Bai Y, Jin J, Liu Z, Jin Y, Li P, Cao C, Liu X. Dong Q, et al. Cell Death Dis. 2022 Apr 4;13(4):298. doi: 10.1038/s41419-022-04748-2. Cell Death Dis. 2022. PMID: 35379774 Free PMC article.
• The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling.
  Pal P, Hales K, Hales DB. Pal P, et al. Oncotarget. 2020 Oct 6;11(40):3646-3659. doi: 10.18632/oncotarget.27760. eCollection 2020 Oct 6. Oncotarget. 2020. PMID: 33088425 Free PMC article.
• Propofol inhibits the expression of Abelson nonreceptor tyrosine kinase without affecting learning or memory function in neonatal rats.
  Feng L, Sun ZG, Liu QW, Ma T, Xu ZP, Feng ZG, Yuan WX, Zhang H, Xu LH. Feng L, et al. Brain Behav. 2020 Nov;10(11):e01810. doi: 10.1002/brb3.1810. Epub 2020 Sep 1. Brain Behav. 2020. PMID: 32869521 Free PMC article.
• α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment.
  Karim MR, Liao EE, Kim J, Meints J, Martinez HM, Pletnikova O, Troncoso JC, Lee MK. Karim MR, et al. Mol Neurodegener. 2020 Apr 16;15(1):27. doi: 10.1186/s13024-020-00364-w. Mol Neurodegener. 2020. PMID: 32299471 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal