Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death - PubMed (original) (raw)

. 2000 Mar 2;19(10):1346-53.

doi: 10.1038/sj.onc.1203429.

Affiliations

• PMID: 10713676
• DOI: 10.1038/sj.onc.1203429

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

A Suzuki et al. Oncogene. 2000.

Abstract

Caspase 3 is an essential death factor for the Fas-mediated cell death, and its inactivation in cells is initiated by an interaction with p21 on mitochondria or with IAP family member ILP. Survivin is also a member of IAP family and is specifically expressed during embryogenesis and in tumor cells and suppresses cell death signaling. In our current study, we demonstrated that Survivin translocation into the nucleus is dependent on Fas stimulation and cell proliferation. Survivin also interacts with the cell cycle regulator Cdk4, leading to Cdk2/Cyclin E activation and Rb phosphorylation. As a result of Survivin/Cdk4 complex formation, p21 is released from its complex with Cdk4 and interacts with mitochondrial procaspase 3 to suppress Fas-mediated cell death. Here, we propose that Survivin supports procaspase 3/p21 complex formation as a result of interaction with Cdk4 resulting in suppression of cell death signaling.

PubMed Disclaimer

Similar articles

• Procaspase 3/p21 complex formation to resist fas-mediated cell death is initiated as a result of the phosphorylation of p21 by protein kinase A.
  Suzuki A, Kawano H, Hayashida M, Hayasaki Y, Tsutomi Y, Akahane K. Suzuki A, et al. Cell Death Differ. 2000 Aug;7(8):721-8. doi: 10.1038/sj.cdd.4400706. Cell Death Differ. 2000. PMID: 10918446
• Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21.
  Suzuki A, Tsutomi Y, Miura M, Akahane K. Suzuki A, et al. Oncogene. 1999 Feb 4;18(5):1239-44. doi: 10.1038/sj.onc.1202409. Oncogene. 1999. PMID: 10022130
• Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP.
  Suzuki A, Tsutomi Y, Akahane K, Araki T, Miura M. Suzuki A, et al. Oncogene. 1998 Aug 27;17(8):931-9. doi: 10.1038/sj.onc.1202021. Oncogene. 1998. PMID: 9747872
• Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.
  Suzuki A, Hayashida M, Ito T, Kawano H, Nakano T, Miura M, Akahane K, Shiraki K. Suzuki A, et al. Oncogene. 2000 Jul 6;19(29):3225-34. doi: 10.1038/sj.onc.1203665. Oncogene. 2000. PMID: 10918579
• Tumor cell "dead or alive": caspase and survivin regulate cell death, cell cycle and cell survival.
  Suzuki A, Shiraki K. Suzuki A, et al. Histol Histopathol. 2001 Apr;16(2):583-93. doi: 10.14670/HH-16.583. Histol Histopathol. 2001. PMID: 11332714 Review.

Cited by

• Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/_β_-Catenin Pathway.
  Wen Y, Li Y, Yang B, Guo X, Lin L, Liang J, Zhang K, Li X, Jiang Z, Wang Y, Li Y, Wu X, Fan X, Li F, Yuan W. Wen Y, et al. Dis Markers. 2022 Nov 8;2022:6993994. doi: 10.1155/2022/6993994. eCollection 2022. Dis Markers. 2022. PMID: 36398031 Free PMC article.
• Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma.
  Udoh US, Banerjee M, Rajan PK, Sanabria JD, Smith G, Schade M, Sanabria JA, Nakafuku Y, Sodhi K, Pierre SV, Shapiro JI, Sanabria JR. Udoh US, et al. Int J Mol Sci. 2022 Jul 1;23(13):7359. doi: 10.3390/ijms23137359. Int J Mol Sci. 2022. PMID: 35806364 Free PMC article.
• Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A.
  Narayan S, Raza A, Mahmud I, Koo N, Garrett TJ, Law ME, Law BK, Sharma AK. Narayan S, et al. iScience. 2022 Jun 3;25(7):104518. doi: 10.1016/j.isci.2022.104518. eCollection 2022 Jul 15. iScience. 2022. PMID: 35754740 Free PMC article.
• A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells.
  Peery R, Cui Q, Kyei-Baffour K, Josephraj S, Huang C, Dong Z, Dai M, Zhang JT, Liu JY. Peery R, et al. Bioorg Med Chem. 2022 Jul 1;65:116761. doi: 10.1016/j.bmc.2022.116761. Epub 2022 Apr 28. Bioorg Med Chem. 2022. PMID: 35504208 Free PMC article.
• Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway.
  Zhu XQ, Yang H, Lin MH, Shang HX, Peng J, Chen WJ, Chen XZ, Lin JM. Zhu XQ, et al. J Gastrointest Oncol. 2020 Dec;11(6):1123-1134. doi: 10.21037/jgo-20-213. J Gastrointest Oncol. 2020. PMID: 33456987 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal