Structural alterations in rat skin and bone collagen fibrils induced by ovariectomy - PubMed (original) (raw)
Structural alterations in rat skin and bone collagen fibrils induced by ovariectomy
H Kafantari et al. Bone. 2000 Apr.
Abstract
In this study, the influence of ovariectomy in rat skin and bone (trabecular and cortical) collagen fibrils is examined using electron microscopy. Structural changes (fibril architecture and diameter) were detected, at the ultrastructural level, in skin and bone specimens from ovariectomized rats. The overall collagen fibril architecture was disturbed as compared with normal animals. Treated collagen fibrils' mean diameter values were significantly smaller than those from controls, in all tissues examined. The banding patterns of fibrils were normal in all cases; however, measurements by a computerized method of measuring axial periodicity of fibrils indicated significantly lower values for treated samples than untreated samples. Our results show a correlation between the effects induced by ovariectomy in skin and bone collagen. But, the question of whether these changes play a role in the pathogenesis of ovarian hormone deficiency in osteoporosis remains to be demonstrated.
Similar articles
- The influence of inflammation-mediated osteopenia (IMO) on the structure of rabbit bone and skin collagen fibrils.
Kounadi E, Fountos G, Tzaphlidou M. Kounadi E, et al. Connect Tissue Res. 1998;37(1-2):69-76. doi: 10.3109/03008209809028901. Connect Tissue Res. 1998. PMID: 9643648 - The role of collagen in bone structure: an image processing approach.
Tzaphlidou M. Tzaphlidou M. Micron. 2005;36(7-8):593-601. doi: 10.1016/j.micron.2005.05.009. Epub 2005 Sep 1. Micron. 2005. PMID: 16209926 Review. - Evaluation of modal damping factor as a diagnostic tool for osteoporosis and its relation with serum osteocalcin and collagen I N-telopeptide for monitoring the efficacy of alendronate in ovariectomized rats.
Christopoulou GE, Stavropoulou A, Anastassopoulos G, Panteliou SD, Papadaki E, Karamanos NK, Panagiotopoulos E. Christopoulou GE, et al. J Pharm Biomed Anal. 2006 Jun 7;41(3):891-7. doi: 10.1016/j.jpba.2005.12.038. Epub 2006 Feb 20. J Pharm Biomed Anal. 2006. PMID: 16488571 - Collagenous tissues upon lithium treatment: a quantitative ultrastructural study.
Tzaphlidou M. Tzaphlidou M. ScientificWorldJournal. 2004 Aug 11;4:605-21. doi: 10.1100/tsw.2004.119. ScientificWorldJournal. 2004. PMID: 15349503 Free PMC article. Review. - Collagen fibril diameter in relation to bone site. a quantitative ultrastructural study.
Tzaphlidou M, Berillis P. Tzaphlidou M, et al. Micron. 2005;36(7-8):703-5. doi: 10.1016/j.micron.2005.05.012. Epub 2005 Sep 7. Micron. 2005. PMID: 16182541
Cited by
- Gene Therapy for Skin Aging.
Saad FA. Saad FA. Curr Gene Ther. 2024;25(1):2-9. doi: 10.2174/0115665232286489240320051925. Curr Gene Ther. 2024. PMID: 38529607 Review. - Investigating Osteocytic Perilacunar/Canalicular Remodeling.
Yee CS, Schurman CA, White CR, Alliston T. Yee CS, et al. Curr Osteoporos Rep. 2019 Aug;17(4):157-168. doi: 10.1007/s11914-019-00514-0. Curr Osteoporos Rep. 2019. PMID: 31227998 Free PMC article. Review. - Ultrastructural observation of electron irradiation damage of lamellar bone.
Hong SI, Hong SK, Wallace JM, Kohn DH. Hong SI, et al. J Mater Sci Mater Med. 2009 Apr;20(4):959-65. doi: 10.1007/s10856-008-3651-7. Epub 2008 Nov 26. J Mater Sci Mater Med. 2009. PMID: 19034616 - Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency.
Sharma D, Ciani C, Marin PA, Levy JD, Doty SB, Fritton SP. Sharma D, et al. Bone. 2012 Sep;51(3):488-97. doi: 10.1016/j.bone.2012.05.014. Epub 2012 May 23. Bone. 2012. PMID: 22634177 Free PMC article. - Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin.
Markiewicz M, Asano Y, Znoyko S, Gong Y, Watson DK, Trojanowska M. Markiewicz M, et al. J Dermatol Sci. 2007 Sep;47(3):217-26. doi: 10.1016/j.jdermsci.2007.05.008. Epub 2007 Jun 29. J Dermatol Sci. 2007. PMID: 17601707 Free PMC article.