Development of sensory neurons in the absence of NGF/TrkA signaling in vivo - PubMed (original) (raw)
Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
T D Patel et al. Neuron. 2000 Feb.
Free article
Erratum in
- Neuron. 2003 Jan 9;37(1):183
Abstract
The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is also eliminated. These neurons extend axons through the dorsal roots and collateral branches into the dorsal horn. In contrast, superficial cutaneous innervation is absent. Furthermore, rescued sensory neurons fail to express biochemical markers characteristic of the nociceptive phenotype. These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons.
Comment in
- Center stage for NGF in peripheral (but not central) sensory neuron outgrowth.
Kaplan D, Zirrgiebel U, Atwal J. Kaplan D, et al. Neuron. 2000 Feb;25(2):253-4. doi: 10.1016/s0896-6273(00)80887-9. Neuron. 2000. PMID: 10719878 Review. No abstract available.
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