Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia - PubMed (original) (raw)
Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
A Ramón-Cueto et al. Neuron. 2000 Feb.
Free article
Abstract
Axonal regeneration in the lesioned mammalian central nervous system is abortive, and this causes permanent disabilities in individuals with spinal cord injuries. In adult rats, olfactory ensheathing glia (OEG) transplants successfully led to functional and structural recovery after complete spinal cord transection. From 3 to 7 months post surgery, all OEG-transplanted animals recovered locomotor functions and sensorimotor reflexes. They presented voluntary hindlimb movements, they supported their body weight, and their hindlimbs responded to light skin contact and proprioceptive stimuli. In addition, relevant motor axons (corticospinal, raphespinal, and coeruleospinal) regenerated for long distances within caudal cord stumps. Therefore, OEG transplantation provides a useful repair strategy in adult mammals with traumatic spinal cord injuries. Our results with these cells could lead to new therapies for the treatment of spinal cord lesions in humans.
Similar articles
- Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the contused adult rat spinal cord.
Plant GW, Christensen CL, Oudega M, Bunge MB. Plant GW, et al. J Neurotrauma. 2003 Jan;20(1):1-16. doi: 10.1089/08977150360517146. J Neurotrauma. 2003. PMID: 12614584 - Noradrenergic innervation of the rat spinal cord caudal to a complete spinal cord transection: effects of olfactory ensheathing glia.
Takeoka A, Kubasak MD, Zhong H, Kaplan J, Roy RR, Phelps PE. Takeoka A, et al. Exp Neurol. 2010 Mar;222(1):59-69. doi: 10.1016/j.expneurol.2009.12.008. Epub 2009 Dec 16. Exp Neurol. 2010. PMID: 20025875 Free PMC article. - Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.
Ziegler MD, Hsu D, Takeoka A, Zhong H, Ramón-Cueto A, Phelps PE, Roy RR, Edgerton VR. Ziegler MD, et al. Exp Neurol. 2011 May;229(1):109-19. doi: 10.1016/j.expneurol.2011.01.007. Epub 2011 Jan 25. Exp Neurol. 2011. PMID: 21272578 Free PMC article. - Olfactory ensheathing glia: their contribution to primary olfactory nervous system regeneration and their regenerative potential following transplantation into the injured spinal cord.
Franssen EH, de Bree FM, Verhaagen J. Franssen EH, et al. Brain Res Rev. 2007 Nov;56(1):236-58. doi: 10.1016/j.brainresrev.2007.07.013. Epub 2007 Aug 14. Brain Res Rev. 2007. PMID: 17884174 Review. - Olfactory ensheathing glia transplantation: a therapy to promote repair in the mammalian central nervous system.
Santos-Benito FF, Ramón-Cueto A. Santos-Benito FF, et al. Anat Rec B New Anat. 2003 Mar;271(1):77-85. doi: 10.1002/ar.b.10015. Anat Rec B New Anat. 2003. PMID: 12619089 Review.
Cited by
- Chemotactic TEG3 Cells' Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1α/CXCL12 Chemokine for Neural Regeneration Therapy.
Castaño O, López-Mengual A, Reginensi D, Matamoros-Angles A, Engel E, Del Rio JA. Castaño O, et al. Front Bioeng Biotechnol. 2021 Mar 22;9:627805. doi: 10.3389/fbioe.2021.627805. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 33829009 Free PMC article. - Three-dimensional Collagen Scaffolds in Cultures of Olfactory Ensheathing Cells Used for Severed Spinal Cord Regeneration.
Fortuna W, Wiatrak B, Jawień P, Kubis-Kubiak A, Li Y, Li D, Tabakow P. Fortuna W, et al. In Vivo. 2022 Sep-Oct;36(5):2032-2041. doi: 10.21873/invivo.12929. In Vivo. 2022. PMID: 36099107 Free PMC article. - Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis.
Hamilton L, Franklin RJ, Jeffery ND. Hamilton L, et al. BMC Neurosci. 2007 Sep 18;8:77. doi: 10.1186/1471-2202-8-77. BMC Neurosci. 2007. PMID: 17877823 Free PMC article. - Basic advances and new avenues in therapy of spinal cord injury.
Dobkin BH, Havton LA. Dobkin BH, et al. Annu Rev Med. 2004;55:255-82. doi: 10.1146/annurev.med.55.091902.104338. Annu Rev Med. 2004. PMID: 14746521 Free PMC article. Review. - A Modular Assembly of Spinal Cord-Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord.
Lai BQ, Feng B, Che MT, Wang LJ, Cai S, Huang MY, Gu HY, Jiang B, Ling EA, Li M, Zeng X, Zeng YS. Lai BQ, et al. Adv Sci (Weinh). 2018 Jul 20;5(9):1800261. doi: 10.1002/advs.201800261. eCollection 2018 Sep. Adv Sci (Weinh). 2018. PMID: 30250785 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources