A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins - PubMed (original) (raw)

A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins

D L Jack et al. J Bacteriol. 2000 Apr.

Abstract

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

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References

    1. Brown M H, Paulsen I T, Skurray R A. The multidrug efflux protein NorM is a prototype of a new family of transporters. Mol Microbiol. 1999;31:394–395. - PubMed
    1. Guzman L-M, Belin D, Carson M J, Beckwith J. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol. 1995;177:4121–4130. - PMC - PubMed
    1. Mitchell B A, Paulsen I T, Brown M H, Skurray R A. Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations. J Biol Chem. 1999;274:3541–3548. - PubMed
    1. Mordoch S S, Granot D, Lebendiker M, Schuldiner S. Scanning cysteine accessibility of EmrE, an H+-coupled multidrug transporter from Escherichia coli, reveals a hydrophobic pathway for solutes. J Biol Chem. 1999;274:19480–19486. - PubMed
    1. Paulsen I T, Skurray R A, Tam R, Saier M H, Jr, Turner R J, Weiner J H, Goldberg E B, Grinius L L. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol. 1996;19:1167–1175. - PubMed

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