A Drosophila model of Parkinson's disease - PubMed (original) (raw)

. 2000 Mar 23;404(6776):394-8.

doi: 10.1038/35006074.

Affiliations

• PMID: 10746727
• DOI: 10.1038/35006074

A Drosophila model of Parkinson's disease

M B Feany et al. Nature. 2000.

Abstract

Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.

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Comment in

• Parkinson's pathology in a fly.
  Haass C, Kahle PJ. Haass C, et al. Nature. 2000 Mar 23;404(6776):341, 343. doi: 10.1038/35006188. Nature. 2000. PMID: 10746706 No abstract available.

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