Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity - PubMed (original) (raw)

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

M Rocheville et al. Science. 2000.

Abstract

Somatostatin and dopamine are two major neurotransmitter systems that share a number of structural and functional characteristics. Somatostatin receptors and dopamine receptors are colocalized in neuronal subgroups, and somatostatin is involved in modulating dopamine-mediated control of motor activity. However, the molecular basis for such interaction between the two systems is unclear. Here, we show that dopamine receptor D2R and somatostatin receptor SSTR5 interact physically through hetero-oligomerization to create a novel receptor with enhanced functional activity. Our results provide evidence that receptors from different G protein (heterotrimeric guanine nucleotide binding protein)-coupled receptor families interact through oligomerization. Such direct intramembrane association defines a new level of molecular crosstalk between related G protein-coupled receptor subfamilies.

PubMed Disclaimer

Comment in

• Neurobiology. Receptors as kissing cousins.
  Milligan G. Milligan G. Science. 2000 Apr 7;288(5463):65-7. doi: 10.1126/science.288.5463.65. Science. 2000. PMID: 10766637 No abstract available.

Similar articles

• Neurobiology. Receptors as kissing cousins.
  Milligan G. Milligan G. Science. 2000 Apr 7;288(5463):65-7. doi: 10.1126/science.288.5463.65. Science. 2000. PMID: 10766637 No abstract available.
• Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
  Di Marzo V, Vial D, Sokoloff P, Schwartz JC, Piomelli D. Di Marzo V, et al. J Neurosci. 1993 Nov;13(11):4846-53. doi: 10.1523/JNEUROSCI.13-11-04846.1993. J Neurosci. 1993. PMID: 7693893 Free PMC article.
• Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines.
  Kuzhikandathil EV, Yu W, Oxford GS. Kuzhikandathil EV, et al. Mol Cell Neurosci. 1998 Dec;12(6):390-402. doi: 10.1006/mcne.1998.0722. Mol Cell Neurosci. 1998. PMID: 9888991
• Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.
  Agnati LF, Ferré S, Lluis C, Franco R, Fuxe K. Agnati LF, et al. Pharmacol Rev. 2003 Sep;55(3):509-50. doi: 10.1124/pr.55.3.2. Epub 2003 Jul 17. Pharmacol Rev. 2003. PMID: 12869660 Review.
• Relevance of coexpression of somatostatin and dopamine D2 receptors in pituitary adenomas.
  Saveanu A, Jaquet P, Brue T, Barlier A. Saveanu A, et al. Mol Cell Endocrinol. 2008 May 14;286(1-2):206-13. doi: 10.1016/j.mce.2007.12.008. Epub 2007 Dec 23. Mol Cell Endocrinol. 2008. PMID: 18241980 Review.

Cited by

• Current and Emerging Pharmacological Therapies for Cushing's Disease.
  Divaris E, Kostopoulos G, Efstathiadou ZA. Divaris E, et al. Curr Pharm Des. 2024;30(10):757-777. doi: 10.2174/0113816128290025240216110928. Curr Pharm Des. 2024. PMID: 38424426 Review.
• Activation, internalization, and recycling of the serotonin 2A receptor by dopamine.
  Bhattacharyya S, Raote I, Bhattacharya A, Miledi R, Panicker MM. Bhattacharyya S, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15248-53. doi: 10.1073/pnas.0606578103. Epub 2006 Sep 27. Proc Natl Acad Sci U S A. 2006. PMID: 17005723 Free PMC article.
• Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence.
  Daniele S, Saporiti S, Capaldi S, Pietrobono D, Russo L, Guerrini U, Laurenzi T, Ataie Kachoie E, Palazzolo L, Russo V, Abbracchio MP, Eberini I, Trincavelli ML. Daniele S, et al. Int J Mol Sci. 2022 Dec 23;24(1):261. doi: 10.3390/ijms24010261. Int J Mol Sci. 2022. PMID: 36613703 Free PMC article.
• Medical therapy of acromegaly: efficacy and safety of somatostatin analogues.
  Feelders RA, Hofland LJ, van Aken MO, Neggers SJ, Lamberts SW, de Herder WW, van der Lely AJ. Feelders RA, et al. Drugs. 2009 Nov 12;69(16):2207-26. doi: 10.2165/11318510-000000000-00000. Drugs. 2009. PMID: 19852525 Review.
• Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.
  Werry TD, Wilkinson GF, Willars GB. Werry TD, et al. Biochem J. 2003 Sep 1;374(Pt 2):281-96. doi: 10.1042/BJ20030312. Biochem J. 2003. PMID: 12790797 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database