LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response - PubMed (original) (raw)
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response
K Tamada et al. J Immunol. 2000.
Abstract
LIGHT is a recently identified member of the TNF superfamily and its receptors, herpesvirus entry mediator and lymphotoxin beta receptor, are found in T cells and stromal cells. In this study, we demonstrate that LIGHT is selectively expressed on immature dendritic cells (DCs) generated from human PBMCs. In contrast, LIGHT is not detectable in DCs either freshly isolated from PBMCs or rendered mature in vitro by LPS treatment. Blockade of LIGHT by its soluble receptors, lymphotoxin beta receptor-Ig or HVEM-Ig, inhibits the induction of DC-mediated primary allogeneic T cell response. Furthermore, engagement of LIGHT costimulates human T cell proliferation, amplifies the NF-kappaB signaling pathway, and preferentially induces the production of IFN-gamma, but not IL-4, in the presence of an antigenic signal. Our results suggest that LIGHT is a costimulatory molecule involved in DC-mediated cellular immune responses.
Similar articles
- Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines.
Harrop JA, Reddy M, Dede K, Brigham-Burke M, Lyn S, Tan KB, Silverman C, Eichman C, DiPrinzio R, Spampanato J, Porter T, Holmes S, Young PR, Truneh A. Harrop JA, et al. J Immunol. 1998 Aug 15;161(4):1786-94. J Immunol. 1998. PMID: 9712045 - The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity.
Morel Y, Truneh A, Sweet RW, Olive D, Costello RT. Morel Y, et al. J Immunol. 2001 Sep 1;167(5):2479-86. doi: 10.4049/jimmunol.167.5.2479. J Immunol. 2001. PMID: 11509586 - Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor.
Morel Y, Schiano de Colella JM, Harrop J, Deen KC, Holmes SD, Wattam TA, Khandekar SS, Truneh A, Sweet RW, Gastaut JA, Olive D, Costello RT. Morel Y, et al. J Immunol. 2000 Oct 15;165(8):4397-404. doi: 10.4049/jimmunol.165.8.4397. J Immunol. 2000. PMID: 11035077 - The role of LIGHT in T cell-mediated immunity.
Wang J, Fu YX. Wang J, et al. Immunol Res. 2004;30(2):201-14. doi: 10.1385/IR:30:2:201. Immunol Res. 2004. PMID: 15477661 Review. - LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Granger SW, Rickert S. Granger SW, et al. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):289-96. doi: 10.1016/s1359-6101(03)00031-5. Cytokine Growth Factor Rev. 2003. PMID: 12787566 Review.
Cited by
- Augmenting CAR T-cell Functions with LIGHT.
Cai W, Tanaka K, Mi X, Rajasekhar VK, Khan JF, Yoo S, de Stanchina E, Rahman J, Mathew S, Abrahimi P, Souness S, Purdon TJ, McDowell JR, Meyerberg J, Fujino T, Healey JH, Abdel-Wahab O, Scheinberg DA, Brentjens RJ, Daniyan AF. Cai W, et al. Cancer Immunol Res. 2024 Oct 1;12(10):1361-1379. doi: 10.1158/2326-6066.CIR-24-0246. Cancer Immunol Res. 2024. PMID: 38959337 - Multilayered Computational Framework for Designing Peptide Inhibitors of HVEM-LIGHT Interaction.
Ciura P, Smardz P, Spodzieja M, Sieradzan AK, Krupa P. Ciura P, et al. J Phys Chem B. 2024 Jul 18;128(28):6770-6785. doi: 10.1021/acs.jpcb.4c02255. Epub 2024 Jul 3. J Phys Chem B. 2024. PMID: 38958133 Free PMC article. - Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer's Disease.
Pulliam L, Sun B, McCafferty E, Soper SA, Witek MA, Hu M, Ford JM, Song S, Kapogiannis D, Glesby MJ, Merenstein D, Tien PC, Freasier H, French A, McKay H, Diaz MM, Ofotokun I, Lake JE, Margolick JB, Kim EY, Levine SR, Fischl MA, Li W, Martinson J, Tang N. Pulliam L, et al. Int J Mol Sci. 2024 Mar 29;25(7):3830. doi: 10.3390/ijms25073830. Int J Mol Sci. 2024. PMID: 38612641 Free PMC article. - Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review.
Tang L, Xu H, Wu T, Wu W, Lu Y, Gu J, Wang X, Zhou M, Chen Q, Sun X, Cai H. Tang L, et al. Discov Oncol. 2024 Apr 11;15(1):111. doi: 10.1007/s12672-024-00902-8. Discov Oncol. 2024. PMID: 38602556 Free PMC article. Review. - CD169+ classical monocyte as an important participant in Graves' ophthalmopathy through CXCL12-CXCR4 axis.
Wang D, Ling J, Tan R, Wang H, Qu Y, Li X, Lin J, Zhang Q, Hu Q, Liu Z, Lu Z, Lin Y, Sun L, Wang D, Zhou M, Shi Z, Gao W, Ye H, Lin X. Wang D, et al. iScience. 2024 Feb 10;27(3):109213. doi: 10.1016/j.isci.2024.109213. eCollection 2024 Mar 15. iScience. 2024. PMID: 38439953 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous