Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors - PubMed (original) (raw)
Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors
S N Agoff et al. Mod Pathol. 2000 Mar.
Abstract
Thyroid transcription factor-1 (TTF-1) is a nuclear homeodomain transcription factor that is expressed in the developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in pulmonary or thyroid neoplasms, and it is expressed in a significant subset of pulmonary non-small cell carcinomas, small cell carcinomas, and carcinoids but not in nonpulmonary, non-small cell carcinomas. Neuroendocrine tumors from sites other than the lung have not been evaluated for TFF-1 expression. We examined TFF-1 expression using immunohistochemistry on formalin-fixed, paraffin-embedded sections of 49 gastrointestinal carcinoids; 15 pancreatic islet cell tumors; 21 paragangliomas; 8 medullary thyroid carcinomas; 7 small cell carcinomas of the uterine cervix; 4 prostate, 4 bladder, and 6 Merkel cell (primary cutaneous neuroendocrine) carcinomas; and 1 renal carcinoma No gastrointestinal carcinoid tumor, pancreatic islet cell tumor, paraganglioma, or Merkel cell carcinoma expressed TFF-1. All of the medullary thyroid carcinomas strongly expressed TTF-1. However, 44% of nonpulmonary small cell carcinomas were also TTF-1 positive, including four of four prostate, two of four bladder, and one of seven cervical small cell carcinomas. We conclude that TTF-1 expression is not specific for small cell carcinomas of pulmonary origin and should not be used to distinguish primary from metastatic small cell carcinomas in extrapulmonary sites. However, TTF-1 expression may be useful in distinguishing Merkel cell carcinomas and cutaneous metastasis of small cell carcinomas. Among well-differentiated neuroendocrine tumors, TTF-1 expression seems to be present only in carcinoid tumors of the lung and medullary carcinomas of the thyroid and may be of differential diagnostic value when dealing with a metastatic well-differentiated neuroendocrine tumor.
Similar articles
- Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas.
Ordóñez NG. Ordóñez NG. Am J Surg Pathol. 2000 Sep;24(9):1217-23. doi: 10.1097/00000478-200009000-00004. Am J Surg Pathol. 2000. PMID: 10976695 - Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases.
Jones TD, Kernek KM, Yang XJ, Lopez-Beltran A, MacLennan GT, Eble JN, Lin H, Pan CX, Tretiakova M, Baldridge LA, Cheng L. Jones TD, et al. Hum Pathol. 2005 Jul;36(7):718-23. doi: 10.1016/j.humpath.2005.04.007. Hum Pathol. 2005. PMID: 16084939 - Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors.
Cai YC, Banner B, Glickman J, Odze RD. Cai YC, et al. Hum Pathol. 2001 Oct;32(10):1087-93. doi: 10.1053/hupa.2001.28245. Hum Pathol. 2001. PMID: 11679943 - Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma.
Woodruff JM, Huvos AG, Erlandson RA, Shah JP, Gerold FP. Woodruff JM, et al. Am J Surg Pathol. 1985 Nov;9(11):771-90. Am J Surg Pathol. 1985. PMID: 2866724 Review. - Carcinomas of the lung with neuroendocrine differentiation.
Carter D, Yesner R. Carter D, et al. Semin Diagn Pathol. 1985 Nov;2(4):235-54. Semin Diagn Pathol. 1985. PMID: 3039628 Review.
Cited by
- First reported case of primary small cell cancer of the pancreas with positive TTF-1 tumor marker.
Al-Obaidi H, Moliya P, Al-Obaidi AD, Harb H, Al-Badri SG, Hashim HT, Agha I, Mora M, Merza N, Othman A, Patel A. Al-Obaidi H, et al. Radiol Case Rep. 2024 Sep 6;19(12):5595-5599. doi: 10.1016/j.radcr.2024.08.034. eCollection 2024 Dec. Radiol Case Rep. 2024. PMID: 39296748 Free PMC article. - Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review.
Sun Y, Zhang Y, Li R, Cai D, Zhang W, Yang Z. Sun Y, et al. Front Oncol. 2023 Sep 13;13:1222961. doi: 10.3389/fonc.2023.1222961. eCollection 2023. Front Oncol. 2023. PMID: 37771442 Free PMC article. Review. - Canadian Consensus Recommendations on the Management of Extensive-Stage Small-Cell Lung Cancer.
Melosky BL, Leighl NB, Dawe D, Blais N, Wheatley-Price PF, Chu QS, Juergens RA, Ellis PM, Sun A, Schellenberg D, Ionescu DN, Cheema PK. Melosky BL, et al. Curr Oncol. 2023 Jun 30;30(7):6289-6315. doi: 10.3390/curroncol30070465. Curr Oncol. 2023. PMID: 37504325 Free PMC article. Review. - Cutaneous lesions in a COVID-19 patient leading to a surprising diagnosis.
Tsakiri K, Ouranos K, Nikolaidou C, Papadopoulos S, Andreadou A, Mouloudi E, Massa E. Tsakiri K, et al. Breathe (Sheff). 2023 Mar;19(1):220233. doi: 10.1183/20734735.0233-2022. Epub 2023 Apr 11. Breathe (Sheff). 2023. PMID: 37378064 Free PMC article. - Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.
Crescenzi A, Baloch Z. Crescenzi A, et al. Front Endocrinol (Lausanne). 2023 May 31;14:1198099. doi: 10.3389/fendo.2023.1198099. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37324272 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical