Red cells II: acquired anaemias and polycythaemia - PubMed (original) (raw)
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Red cells II: acquired anaemias and polycythaemia
D Provan et al. Lancet. 2000.
Abstract
Iron deficiency affects 30% of the world's population. Iron metabolism is tightly regulated, with both gut transport and storage being coordinated. Hereditary haemochromatosis due to mutations in the HFE gene leads to increased absorption of iron and multiple end-organ damage. Myelodysplastic disorders are acquired clonal stem-cell disorders that cause ineffective erythropoiesis. Aplastic anaemia is caused by an intrinsic defect of haemopoietic stem cells; both inherited and acquired forms occur. Primary polycythaemia is a myeloproliferative disorder, a non-malignant stem-cell disease.
Comment in
- Acquired anaemias and polycythaemia.
Durand JM, Jean R, Crétel E, Branger S. Durand JM, et al. Lancet. 2000 Aug 12;356(9229):596. doi: 10.1016/S0140-6736(05)73977-5. Lancet. 2000. PMID: 10950260 No abstract available. - Acquired anaemias and polycythaemia.
Djulbegovic B. Djulbegovic B. Lancet. 2000 Aug 12;356(9229):596. doi: 10.1016/S0140-6736(05)73978-7. Lancet. 2000. PMID: 10950261 No abstract available. - Acquired anaemia and polycythaemia.
Rougemont A, Delley-Michel V, Brenner E. Rougemont A, et al. Lancet. 2000 Jul 15;356(9225):251. doi: 10.1016/S0140-6736(05)74501-3. Lancet. 2000. PMID: 10963223 No abstract available.
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