Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species - PubMed (original) (raw)
. 2000 Jun 9;275(23):17237-40.
doi: 10.1074/jbc.C000099200.
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- PMID: 10770918
- DOI: 10.1074/jbc.C000099200
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Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species
X Sun et al. J Biol Chem. 2000.
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Abstract
The ubiquitously expressed c-Abl protein tyrosine kinase localizes to both the nucleus and cytoplasm. The nuclear form of c-Abl is activated in the cellular response to genotoxic stress. Here we show that cytoplasmic c-Abl is activated by oxidative stress. The results also demonstrate that mitochondrial cytochrome c is released in the cellular response to H(2)O(2) and that this effect is mediated by a c-Abl-dependent mechanism. In concert with these results, we show that H(2)O(2)-induced apoptosis is attenuated in c-Abl-deficient cells. These findings demonstrate that cytoplasmic c-Abl is involved in the apoptotic response of cells to oxidative stress.
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