Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes - PubMed (original) (raw)

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.

Easton A, Jensen ML, Wang C, Hagedorn PH, Li Y, Weed M, Meredith JE, Guss V, Jones K, Gill M, Krause C, Brown JM, Hunihan L, Natale J, Fernandes A, Lu Y, Polino J, Bookbinder M, Cadelina G, Benitex Y, Sane R, Morrison J, Drexler D, Mercer SE, Bon C, Pandya NJ, Jagasia R, Ou Yang TH, Distler T, Grüninger F, Meldgaard M, Terrigno M, Macor JE, Albright CF, Loy J, Hoeg AM, Olson RE, Cacace AM. Easton A, et al. Mol Ther Nucleic Acids. 2022 Aug 4;29:625-642. doi: 10.1016/j.omtn.2022.07.027. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090761 Free PMC article.

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice.

Barendrecht S, Schreurs A, Geissler S, Sabanov V, Ilse V, Rieckmann V, Eichentopf R, Künemund A, Hietel B, Wussow S, Hoffmann K, Körber-Ferl K, Pandey R, Carter GW, Demuth HU, Holzer M, Roßner S, Schilling S, Preuss C, Balschun D, Cynis H. Barendrecht S, et al. Alzheimers Res Ther. 2023 Jan 14;15(1):16. doi: 10.1186/s13195-022-01144-y. Alzheimers Res Ther. 2023. PMID: 36641439 Free PMC article.