Control of homeostasis of CD8+ memory T cells by opposing cytokines - PubMed (original) (raw)

Control of homeostasis of CD8+ memory T cells by opposing cytokines

C C Ku et al. Science. 2000.

Abstract

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

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