Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase - PubMed (original) (raw)

Comparative Study

. 2000 Jan 31;1490(1-2):163-9.

doi: 10.1016/s0167-4781(99)00221-3.

Affiliations

• PMID: 10786632
• DOI: 10.1016/s0167-4781(99)00221-3

Comparative Study

Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase

S Matsuda et al. Biochim Biophys Acta. 2000.

Abstract

A full-length cDNA encoding a novel protein was isolated and sequenced from a human hepatocellular cDNA library. This cDNA consists of 7037 base pairs and has a predicted open reading frame encoding 1924 amino acids. It possesses an RNA-helicase motif containing a DEXH-box in its amino-terminus and an RNase motif in the carboxy-terminus. From a striking homology to Caenorhabditis elegans K12H4.8, it might be a human homolog of the K12H4.8. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 14q31 near the marker D14S605.

PubMed Disclaimer

Similar articles

• Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.
  Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M. Miyazaki K, et al. Biochim Biophys Acta. 2000 Sep 7;1493(1-2):237-41. doi: 10.1016/s0167-4781(00)00158-5. Biochim Biophys Acta. 2000. PMID: 10978530
• Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3.
  Matsuda S, Miyazaki K, Ichigotani Y, Kurata H, Takenouchi Y, Yamamoto T, Nimura Y, Irimura T, Nakatsugawa S, Hamaguchi M. Matsuda S, et al. Biochim Biophys Acta. 2000 Apr 25;1491(1-3):321-6. doi: 10.1016/s0167-4781(00)00049-x. Biochim Biophys Acta. 2000. PMID: 10760598
• Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family.
  Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M. Ichigotani Y, et al. J Hum Genet. 2000;45(6):378-82. doi: 10.1007/s100380070013. J Hum Genet. 2000. PMID: 11185750
• Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32.
  Zhao Y, Yu L, Fu Q, Chen W, Jiang J, Gao J, Zhao S. Zhao Y, et al. Genomics. 2000 Aug 1;67(3):351-5. doi: 10.1006/geno.2000.6255. Genomics. 2000. PMID: 10936056
• The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
  Tabara H, Yigit E, Siomi H, Mello CC. Tabara H, et al. Cell. 2002 Jun 28;109(7):861-71. doi: 10.1016/s0092-8674(02)00793-6. Cell. 2002. PMID: 12110183

Cited by

• Drosophila as a Model for Human Viral Neuroinfections.
  Benoit I, Di Curzio D, Civetta A, Douville RN. Benoit I, et al. Cells. 2022 Aug 29;11(17):2685. doi: 10.3390/cells11172685. Cells. 2022. PMID: 36078091 Free PMC article. Review.
• A primer on metabolic memory: why existing diabesity treatments fail.
  Copur S, Rossing P, Afsar B, Sag AA, Siriopol D, Kuwabara M, Ortiz A, Kanbay M. Copur S, et al. Clin Kidney J. 2020 Sep 2;14(3):756-767. doi: 10.1093/ckj/sfaa143. eCollection 2021 Mar. Clin Kidney J. 2020. PMID: 34512957 Free PMC article. Review.
• DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk.
  Caroleo AM, De Ioris MA, Boccuto L, Alessi I, Del Baldo G, Cacchione A, Agolini E, Rinelli M, Serra A, Carai A, Mastronuzzi A. Caroleo AM, et al. Front Oncol. 2021 Jan 21;10:614541. doi: 10.3389/fonc.2020.614541. eCollection 2020. Front Oncol. 2021. PMID: 33552988 Free PMC article. Review.
• Genetic Insight into the Domain Structure and Functions of Dicer-Type Ribonucleases.
  Ciechanowska K, Pokornowska M, Kurzyńska-Kokorniak A. Ciechanowska K, et al. Int J Mol Sci. 2021 Jan 9;22(2):616. doi: 10.3390/ijms22020616. Int J Mol Sci. 2021. PMID: 33435485 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource