How to activate p53 - PubMed (original) (raw)

Review

. 2000 Apr 20;10(8):R315-7.

doi: 10.1016/s0960-9822(00)00439-5.

Affiliations

• PMID: 10801407
• DOI: 10.1016/s0960-9822(00)00439-5

Free article

Review

How to activate p53

T Caspari. Curr Biol. 2000.

Free article

Abstract

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal