The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? - PubMed (original) (raw)
Review
The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
I Stec et al. FEBS Lett. 2000.
Free article
Abstract
Upon characterization of WHSC1, a gene mapping to the Wolf-Hirschhorn syndrome critical region and at its C-terminus similar to the Drosophila ASH1/trithorax group proteins, we identified a novel protein domain designated PWWP domain. To gain insight into its structure, evolutionary conservation and its potential functional role, we performed database searches to identify other PWWP domain-containing proteins. We retrieved 39 proteins, and a multiple alignment shows that the domain spans some 70 amino acids. It is present in proteins of nuclear origin and plays a role in cell growth and differentiation. Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein-protein interactions.
Similar articles
- WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.
Stec I, Wright TJ, van Ommen GJ, de Boer PA, van Haeringen A, Moorman AF, Altherr MR, den Dunnen JT. Stec I, et al. Hum Mol Genet. 1998 Jul;7(7):1071-82. doi: 10.1093/hmg/7.7.1071. Hum Mol Genet. 1998. PMID: 9618163 - Evolution of the PWWP-domain encoding genes in the plant and animal lineages.
Alvarez-Venegas R, Avramova Z. Alvarez-Venegas R, et al. BMC Evol Biol. 2012 Jun 26;12:101. doi: 10.1186/1471-2148-12-101. BMC Evol Biol. 2012. PMID: 22734652 Free PMC article. - Solution structure of the PWWP domain of the hepatoma-derived growth factor family.
Nameki N, Tochio N, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Fujikura Y, Saito M, Ikari M, Watanabe M, Terada T, Shirouzu M, Yoshida M, Hirota H, Tanaka A, Hayashizaki Y, Güntert P, Kigawa T, Yokoyama S. Nameki N, et al. Protein Sci. 2005 Mar;14(3):756-64. doi: 10.1110/ps.04975305. Epub 2005 Feb 2. Protein Sci. 2005. PMID: 15689505 Free PMC article. - High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.
Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH. Lukasik SM, et al. Protein Sci. 2006 Feb;15(2):314-23. doi: 10.1110/ps.051751706. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384999 Free PMC article. - The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds.
Qiu C, Sawada K, Zhang X, Cheng X. Qiu C, et al. Nat Struct Biol. 2002 Mar;9(3):217-24. doi: 10.1038/nsb759. Nat Struct Biol. 2002. PMID: 11836534 Free PMC article.
Cited by
- Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.
Bhargavan B, Chhunchha B, Fatma N, Kubo E, Kumar A, Singh DP. Bhargavan B, et al. Epigenetics. 2013 Mar;8(3):268-80. doi: 10.4161/epi.23861. Epub 2013 Feb 5. Epigenetics. 2013. PMID: 23386123 Free PMC article. - Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism.
Raz-Prag D, Zeng Y, Sieving PA, Bush RA. Raz-Prag D, et al. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3897-906. doi: 10.1167/iovs.08-3153. Epub 2009 Mar 25. Invest Ophthalmol Vis Sci. 2009. PMID: 19324854 Free PMC article. - p53 and the PWWP domain containing effector proteins in chromatin damage repair.
Hu J, Wang Y. Hu J, et al. Cell Dev Biol. 2013 May 10;2:112. doi: 10.4172/2168-9296.1000112. Cell Dev Biol. 2013. PMID: 25264544 Free PMC article. - Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1.
Zhang Q, Jia KZ, Xia ST, Xu YH, Liu RS, Li HM, Tang YJ. Zhang Q, et al. Sci Rep. 2016 Feb 10;6:20828. doi: 10.1038/srep20828. Sci Rep. 2016. PMID: 26860895 Free PMC article. - Steric Clash in the SET Domain of Histone Methyltransferase NSD1 as a Cause of Sotos Syndrome and Its Genetic Heterogeneity in a Brazilian Cohort.
Ha K, Anand P, Lee JA, Jones JR, Kim CA, Bertola DR, Labonne JD, Layman LC, Wenzel W, Kim HG. Ha K, et al. Genes (Basel). 2016 Nov 9;7(11):96. doi: 10.3390/genes7110096. Genes (Basel). 2016. PMID: 27834868 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases