The mammary fat pad - PubMed (original) (raw)

Review

The mammary fat pad

M C Neville et al. J Mammary Gland Biol Neoplasia. 1998 Apr.

Abstract

The mammary fat pad is essential for development of the mammary epithelium, providing signals that mediate ductal morphogenesis and, probably, alveolar differentiation. The "cleared" fat pad is often used as a transplantation site. Considering the crucial role of the fat pad, its properties have received relatively little attention from researchers in the field. Some of the questions whose investigation is pertinent to understanding both normal mammary development and carcinogenesis are outlined in this commentary in the spirit of stimulating enquiry into this important subject. It is clear from a brief perusal of the available literature that until studies are specifically designed to clearly differentiate between functional effects of the fibrous and the adipose stroma, more substantive information about their differential effects on mammary development and tumorigenesis will not be forthcoming.

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• Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors.
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