Effects of low-frequency transcranial magnetic stimulation on motor excitability and basic motor behavior - PubMed (original) (raw)
Effects of low-frequency transcranial magnetic stimulation on motor excitability and basic motor behavior
W Muellbacher et al. Clin Neurophysiol. 2000 Jun.
Abstract
Objective: To explore effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) on motor excitability and basic motor behavior in humans.
Design and methods: Seven normal volunteers underwent 1 Hz rTMS of the hand representation of the right M1 for 15 min at an intensity of 115% of the individual resting motor threshold. The effects of rTMS on motor excitability were assessed by monitoring changes in individual resting motor threshold and input-output curves of motor evoked potentials (MEPs) in the flexor pollicis brevis, first dorsal interosseus, abductor digiti minimi and biceps brachii muscles. Changes in basic motor behavior were studied by measuring maximal and mean peak force and peak accelerations of thumb flexions and abductions of the fifth finger before and after rTMS.
Results: rTMS produced a significant increase in resting motor threshold and a significant suppression of MEP input-output curves that persisted for 30 min. The suppressing effect was restricted to the hand motor representation which was the prime target of the stimulation procedure, and there were no significant effects on the biceps representation. Peak force and peak acceleration were not affected while the motor representations of muscles involved in the behavioral measurements were significantly suppressed by rTMS.
Conclusions: Low-frequency rTMS of M1 transiently depresses motor excitability but this does not affect basic motor behavior. This is relevant for the therapeutic use of low-frequency rTMS in disorders with abnormal cortical excitability.
Similar articles
- 5 Hz Repetitive Transcranial Magnetic Stimulation with Maximum Voluntary Muscle Contraction Facilitates Cerebral Cortex Excitability of Normal Subjects.
Yin Z, Shen Y, Reinhardt JD, Chen CF, Jiang X, Dai W, Zhang W, Machado S, Arias-Carrion O, Yuan TF, Shan C. Yin Z, et al. CNS Neurol Disord Drug Targets. 2015;14(10):1298-303. doi: 10.2174/1871527315666151111124216. CNS Neurol Disord Drug Targets. 2015. PMID: 26556078 Clinical Trial. - Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses?
Touge T, Gerschlager W, Brown P, Rothwell JC. Touge T, et al. Clin Neurophysiol. 2001 Nov;112(11):2138-45. doi: 10.1016/s1388-2457(01)00651-4. Clin Neurophysiol. 2001. PMID: 11682353 - Low-intensity repetitive transcranial magnetic stimulation decreases motor cortical excitability in humans.
Todd G, Flavel SC, Ridding MC. Todd G, et al. J Appl Physiol (1985). 2006 Aug;101(2):500-5. doi: 10.1152/japplphysiol.01399.2005. Epub 2006 May 4. J Appl Physiol (1985). 2006. PMID: 16675612 Clinical Trial. - Effects of rTMS on the brain: is there value in variability?
Goldsworthy MR, Hordacre B, Rothwell JC, Ridding MC. Goldsworthy MR, et al. Cortex. 2021 Jun;139:43-59. doi: 10.1016/j.cortex.2021.02.024. Epub 2021 Mar 12. Cortex. 2021. PMID: 33827037 Review. - Transcranial magnetic stimulation and bladder function: A systematic review.
Nardone R, Versace V, Sebastianelli L, Brigo F, Golaszewski S, Christova M, Saltuari L, Trinka E. Nardone R, et al. Clin Neurophysiol. 2019 Nov;130(11):2032-2037. doi: 10.1016/j.clinph.2019.08.020. Epub 2019 Sep 3. Clin Neurophysiol. 2019. PMID: 31541980
Cited by
- Inferring causality in brain images: a perturbation approach.
Paus T. Paus T. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1109-14. doi: 10.1098/rstb.2005.1652. Philos Trans R Soc Lond B Biol Sci. 2005. PMID: 16087451 Free PMC article. Review. - Role of the primary motor and dorsal premotor cortices in the anticipation of forces during object lifting.
Chouinard PA, Leonard G, Paus T. Chouinard PA, et al. J Neurosci. 2005 Mar 2;25(9):2277-84. doi: 10.1523/JNEUROSCI.4649-04.2005. J Neurosci. 2005. PMID: 15745953 Free PMC article. - Human motor associative plasticity induced by paired bihemispheric stimulation.
Koganemaru S, Mima T, Nakatsuka M, Ueki Y, Fukuyama H, Domen K. Koganemaru S, et al. J Physiol. 2009 Oct 1;587(Pt 19):4629-44. doi: 10.1113/jphysiol.2009.174342. Epub 2009 Aug 17. J Physiol. 2009. PMID: 19687124 Free PMC article. - Intensity-Dependent Effects of Low-Frequency Subthreshold rTMS on Primary Motor Cortex Excitability and Interhemispheric Inhibition in Elderly Participants: A Randomized Trial.
Wischnewski M, Edwards L, Revill KP, Drake D, Hobbs G, Buetefisch CM. Wischnewski M, et al. Neurorehabil Neural Repair. 2025 Jan;39(1):58-73. doi: 10.1177/15459683241292615. Epub 2024 Oct 27. Neurorehabil Neural Repair. 2025. PMID: 39462433 Free PMC article. Clinical Trial. - Low frequency rTMS over posterior parietal cortex impairs smooth pursuit eye tracking.
Hutton SB, Weekes BS. Hutton SB, et al. Exp Brain Res. 2007 Nov;183(2):195-200. doi: 10.1007/s00221-007-1033-x. Epub 2007 Sep 8. Exp Brain Res. 2007. PMID: 17828394
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources