Effects of low-frequency transcranial magnetic stimulation on motor excitability and basic motor behavior - PubMed (original) (raw)
Effects of low-frequency transcranial magnetic stimulation on motor excitability and basic motor behavior
W Muellbacher et al. Clin Neurophysiol. 2000 Jun.
Abstract
Objective: To explore effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) on motor excitability and basic motor behavior in humans.
Design and methods: Seven normal volunteers underwent 1 Hz rTMS of the hand representation of the right M1 for 15 min at an intensity of 115% of the individual resting motor threshold. The effects of rTMS on motor excitability were assessed by monitoring changes in individual resting motor threshold and input-output curves of motor evoked potentials (MEPs) in the flexor pollicis brevis, first dorsal interosseus, abductor digiti minimi and biceps brachii muscles. Changes in basic motor behavior were studied by measuring maximal and mean peak force and peak accelerations of thumb flexions and abductions of the fifth finger before and after rTMS.
Results: rTMS produced a significant increase in resting motor threshold and a significant suppression of MEP input-output curves that persisted for 30 min. The suppressing effect was restricted to the hand motor representation which was the prime target of the stimulation procedure, and there were no significant effects on the biceps representation. Peak force and peak acceleration were not affected while the motor representations of muscles involved in the behavioral measurements were significantly suppressed by rTMS.
Conclusions: Low-frequency rTMS of M1 transiently depresses motor excitability but this does not affect basic motor behavior. This is relevant for the therapeutic use of low-frequency rTMS in disorders with abnormal cortical excitability.
Similar articles
- 5 Hz Repetitive Transcranial Magnetic Stimulation with Maximum Voluntary Muscle Contraction Facilitates Cerebral Cortex Excitability of Normal Subjects.
Yin Z, Shen Y, Reinhardt JD, Chen CF, Jiang X, Dai W, Zhang W, Machado S, Arias-Carrion O, Yuan TF, Shan C. Yin Z, et al. CNS Neurol Disord Drug Targets. 2015;14(10):1298-303. doi: 10.2174/1871527315666151111124216. CNS Neurol Disord Drug Targets. 2015. PMID: 26556078 Clinical Trial. - Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses?
Touge T, Gerschlager W, Brown P, Rothwell JC. Touge T, et al. Clin Neurophysiol. 2001 Nov;112(11):2138-45. doi: 10.1016/s1388-2457(01)00651-4. Clin Neurophysiol. 2001. PMID: 11682353 - Low-intensity repetitive transcranial magnetic stimulation decreases motor cortical excitability in humans.
Todd G, Flavel SC, Ridding MC. Todd G, et al. J Appl Physiol (1985). 2006 Aug;101(2):500-5. doi: 10.1152/japplphysiol.01399.2005. Epub 2006 May 4. J Appl Physiol (1985). 2006. PMID: 16675612 Clinical Trial. - Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis.
Bai Z, Zhang J, Fong KNK. Bai Z, et al. J Neuroeng Rehabil. 2022 Feb 22;19(1):24. doi: 10.1186/s12984-022-00999-4. J Neuroeng Rehabil. 2022. PMID: 35193624 Free PMC article. Review. - Effects of rTMS on the brain: is there value in variability?
Goldsworthy MR, Hordacre B, Rothwell JC, Ridding MC. Goldsworthy MR, et al. Cortex. 2021 Jun;139:43-59. doi: 10.1016/j.cortex.2021.02.024. Epub 2021 Mar 12. Cortex. 2021. PMID: 33827037 Review.
Cited by
- A multi-center study on low-frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis in post-stroke patients.
Kakuda W, Abo M, Shimizu M, Sasanuma J, Okamoto T, Yokoi A, Taguchi K, Mitani S, Harashima H, Urushidani N, Urashima M; NEURO Investigators. Kakuda W, et al. J Neuroeng Rehabil. 2012 Jan 20;9(1):4. doi: 10.1186/1743-0003-9-4. J Neuroeng Rehabil. 2012. PMID: 22264239 Free PMC article. - Elevated haemoglobin levels in the motor cortex following 1 Hz transcranial magnetic stimulation: a preliminary study.
Chiang TC, Vaithianathan T, Leung T, Lavidor M, Walsh V, Delpy DT. Chiang TC, et al. Exp Brain Res. 2007 Aug;181(4):555-60. doi: 10.1007/s00221-007-0952-x. Epub 2007 May 26. Exp Brain Res. 2007. PMID: 17530233 - Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research.
Rossi S, Hallett M, Rossini PM, Pascual-Leone A; Safety of TMS Consensus Group. Rossi S, et al. Clin Neurophysiol. 2009 Dec;120(12):2008-2039. doi: 10.1016/j.clinph.2009.08.016. Epub 2009 Oct 14. Clin Neurophysiol. 2009. PMID: 19833552 Free PMC article. Review. - A review of combined TMS-EEG studies to characterize lasting effects of repetitive TMS and assess their usefulness in cognitive and clinical neuroscience.
Thut G, Pascual-Leone A. Thut G, et al. Brain Topogr. 2010 Jan;22(4):219-32. doi: 10.1007/s10548-009-0115-4. Epub 2009 Oct 28. Brain Topogr. 2010. PMID: 19862614 Free PMC article. Review. - Transcranial magnetic stimulation, synaptic plasticity and network oscillations.
Huerta PT, Volpe BT. Huerta PT, et al. J Neuroeng Rehabil. 2009 Mar 2;6:7. doi: 10.1186/1743-0003-6-7. J Neuroeng Rehabil. 2009. PMID: 19254380 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources