Connecting transcription to messenger RNA processing - PubMed (original) (raw)

Review

Connecting transcription to messenger RNA processing

N Proudfoot. Trends Biochem Sci. 2000 Jun.

Abstract

The production of messenger RNA by gene transcription requires at least three RNA-processing mechanisms: capping, splicing and polyadenylation. All three reactions occur in intimate association with the elongating polymerase complex through the C terminus of the largest subunit of RNA polymerase II. The processing of mRNA is therefore orchestrated to act on the nascent RNA as soon as it emerges from the polymerase complex.

PubMed Disclaimer

Similar articles

• The mRNA assembly line: transcription and processing machines in the same factory.
  Bentley D. Bentley D. Curr Opin Cell Biol. 2002 Jun;14(3):336-42. doi: 10.1016/s0955-0674(02)00333-2. Curr Opin Cell Biol. 2002. PMID: 12067656 Review.
• The link between mRNA processing and transcription: communication works both ways.
  Zorio DA, Bentley DL. Zorio DA, et al. Exp Cell Res. 2004 May 15;296(1):91-7. doi: 10.1016/j.yexcr.2004.03.019. Exp Cell Res. 2004. PMID: 15120999 Review.
• The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.
  McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL. McCracken S, et al. Nature. 1997 Jan 23;385(6614):357-61. doi: 10.1038/385357a0. Nature. 1997. PMID: 9002523
• On the importance of being co-transcriptional.
  Neugebauer KM. Neugebauer KM. J Cell Sci. 2002 Oct 15;115(Pt 20):3865-71. doi: 10.1242/jcs.00073. J Cell Sci. 2002. PMID: 12244124 Review.
• Coordination between transcription and pre-mRNA processing.
  Cramer P, Srebrow A, Kadener S, Werbajh S, de la Mata M, Melen G, Nogués G, Kornblihtt AR. Cramer P, et al. FEBS Lett. 2001 Jun 8;498(2-3):179-82. doi: 10.1016/s0014-5793(01)02485-1. FEBS Lett. 2001. PMID: 11412852 Review.

Cited by

• Nrd1p identifies aberrant and natural exosomal target messages during the nuclear mRNA surveillance in Saccharomyces cerevisiae.
  Singh P, Chaudhuri A, Banerjea M, Marathe N, Das B. Singh P, et al. Nucleic Acids Res. 2021 Nov 18;49(20):11512-11536. doi: 10.1093/nar/gkab930. Nucleic Acids Res. 2021. PMID: 34664673 Free PMC article.
• Transcriptome Analysis of Core Dinoflagellates Reveals a Universal Bias towards "GC" Rich Codons.
  Williams E, Place A, Bachvaroff T. Williams E, et al. Mar Drugs. 2017 Apr 27;15(5):125. doi: 10.3390/md15050125. Mar Drugs. 2017. PMID: 28448468 Free PMC article.
• Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage.
  Borsos BN, Huliák I, Majoros H, Ujfaludi Z, Gyenis Á, Pukler P, Boros IM, Pankotai T. Borsos BN, et al. Sci Rep. 2017 Jan 19;7:40960. doi: 10.1038/srep40960. Sci Rep. 2017. PMID: 28102346 Free PMC article.
• Control of human papillomavirus gene expression by alternative splicing.
  Graham SV, Faizo AAA. Graham SV, et al. Virus Res. 2017 Mar 2;231:83-95. doi: 10.1016/j.virusres.2016.11.016. Epub 2016 Nov 17. Virus Res. 2017. PMID: 27867028 Free PMC article. Review.
• Human Papillomavirus E2 Regulates SRSF3 (SRp20) To Promote Capsid Protein Expression in Infected Differentiated Keratinocytes.
  Klymenko T, Hernandez-Lopez H, MacDonald AI, Bodily JM, Graham SV. Klymenko T, et al. J Virol. 2016 Apr 29;90(10):5047-58. doi: 10.1128/JVI.03073-15. Print 2016 May 15. J Virol. 2016. PMID: 26962216 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • FlyBase
  • Saccharomyces Genome Database