Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells - PubMed (original) (raw)
Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells
T Budde et al. Neuron. 2000 May.
Free article
Abstract
Ca2+ ions play an important role during rhythmic bursting of thalamocortical neurons within sleep. The function of Ca2+ during the tonic relay mode of these neurons during wakefulness is less clear. Here, we report that tonic activity in thalamocortical cells results in an increase in the intracellular Ca2+ concentration and subsequent release of Ca2+ from intracellular stores mediated via ryanodine receptors (RyRs). Blockade of Ca2+ release shifted the regular firing of single action potentials toward the generation of spike clusters. Regular spike firing and intracellular Ca2+ release thus appear to be functionally coupled in a positive feedback manner, thereby supporting the relay mode of thalamocortical cells during wakefulness. Regulatory influences may be coupled to this system via the cyclic ADP ribose pathway.
Similar articles
- Mechanisms for signal transformation in lemniscal auditory thalamus.
Tennigkeit F, Schwarz DW, Puil E. Tennigkeit F, et al. J Neurophysiol. 1996 Dec;76(6):3597-608. doi: 10.1152/jn.1996.76.6.3597. J Neurophysiol. 1996. PMID: 8985860 - Modulation of Ca2+ currents in rat thalamocortical relay neurons by activity and phosphorylation.
Meuth S, Pape HC, Budde T. Meuth S, et al. Eur J Neurosci. 2002 May;15(10):1603-14. doi: 10.1046/j.1460-9568.2002.01999.x. Eur J Neurosci. 2002. PMID: 12059968 - Intracellular Ca2+ release-dependent inactivation of Ca2+ currents in thalamocortical relay neurons.
Rankovic V, Ehling P, Coulon P, Landgraf P, Kreutz MR, Munsch T, Budde T. Rankovic V, et al. Eur J Neurosci. 2010 Feb;31(3):439-49. doi: 10.1111/j.1460-9568.2010.07081.x. Epub 2010 Jan 25. Eur J Neurosci. 2010. PMID: 20105233 - Novel vistas of calcium-mediated signalling in the thalamus.
Pape HC, Munsch T, Budde T. Pape HC, et al. Pflugers Arch. 2004 May;448(2):131-8. doi: 10.1007/s00424-003-1234-5. Epub 2004 Feb 10. Pflugers Arch. 2004. PMID: 14770314 Review. - The role of T-channels in the generation of thalamocortical rhythms.
Contreras D. Contreras D. CNS Neurol Disord Drug Targets. 2006 Dec;5(6):571-85. doi: 10.2174/187152706779025526. CNS Neurol Disord Drug Targets. 2006. PMID: 17168743 Review.
Cited by
- Low voltage-activated Ca2+ channels are coupled to Ca2+-induced Ca2+ release in rat thalamic midline neurons.
Richter TA, Kolaj M, Renaud LP. Richter TA, et al. J Neurosci. 2005 Sep 7;25(36):8267-71. doi: 10.1523/JNEUROSCI.1942-05.2005. J Neurosci. 2005. PMID: 16148234 Free PMC article. - State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons.
Errington AC, Renger JJ, Uebele VN, Crunelli V. Errington AC, et al. J Neurosci. 2010 Nov 3;30(44):14843-53. doi: 10.1523/JNEUROSCI.2968-10.2010. J Neurosci. 2010. PMID: 21048143 Free PMC article. - Novel modes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons.
Hughes SW, Errington A, Lorincz ML, Kékesi KA, Juhász G, Orbán G, Cope DW, Crunelli V. Hughes SW, et al. Brain Res. 2008 Oct 15;1235:12-20. doi: 10.1016/j.brainres.2008.06.029. Epub 2008 Jun 19. Brain Res. 2008. PMID: 18602904 Free PMC article. Review. - Differential alterations of intracellular [Ca2+] dynamics induced by cocaine and methylphenidate in thalamocortical ventrobasal neurons.
Rozas JL, Goitia B, Bisagno V, Urbano FJ. Rozas JL, et al. Transl Brain Rhythm. 2017 Jul;2(1):10.15761/TBR.1000114. doi: 10.15761/TBR.1000114. Epub 2017 Jul 27. Transl Brain Rhythm. 2017. PMID: 28920083 Free PMC article. - CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain.
Ceni C, Pochon N, Brun V, Muller-Steffner H, Andrieux A, Grunwald D, Schuber F, De Waard M, Lund F, Villaz M, Moutin MJ. Ceni C, et al. Biochem J. 2003 Feb 15;370(Pt 1):175-83. doi: 10.1042/BJ20020604. Biochem J. 2003. PMID: 12403647 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous