Ontogeny of the antibody-forming cell line in mice. I. Kinetics of appearance of mature B cells - PubMed (original) (raw)

Ontogeny of the antibody-forming cell line in mice. I. Kinetics of appearance of mature B cells

Y J Rosenberg et al. Eur J Immunol. 1976 Jul.

Abstract

The development of functionally mature B cells in the liver and spleen of fetal and neonatal CBA mice has been followed. A mature B cell is defined as one giving rise to antibody-producing progeny within 2 days in culture. Very few such B cells are found during fetal life. After birth there is a rapid rise in the numbers reaching 1/3 of adult levels in the 7-day-old spleen.

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