Immune recognition of OxLDL in atherosclerosis - PubMed (original) (raw)
Review
Immune recognition of OxLDL in atherosclerosis
J F Kearney. J Clin Invest. 2000 Jun.
No abstract available
Figures
Figure 1
Potential role of OxLDL and ApoE in autoantibody production. Top: Under normal circumstances, the newly formed IgM+ B-cell population in the perinatal bone marrow or fetal liver can respond to millions of specific antigenic structures. Included in this population are anti-PC clones, some of which carry the T15 idiotype. In the selection step, PC epitopes on apoptotic material or OxLDL (selecting Ag) may enrich for T15/PC-specific B cells. The degree to which this occurs would be limited by the efficiency of debris-scavenging by macrophages or by the availability of ApoE. Additionally, these T15 clones may be stimulated to differentiate by the normally regulated amounts of PC or OxLDL (activating Ag). Bottom: In the absence of ApoE, accumulated OxLDL may promote a still more profound enrichment for T15 clones or may stimulate existing clones to differentiate into T15-producing (natural antibody–producing) plasma cells. Either possibility would give rise to the high levels of anti-OxLDL antibodies observed in the ApoE–/– mice. Circles represent B cells; ovals represent mature antibody-secreting plasma cells. Blue, αPC; yellow, T15/PC.
Comment on
- Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.
Shaw PX, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL. Shaw PX, et al. J Clin Invest. 2000 Jun;105(12):1731-40. doi: 10.1172/JCI8472. J Clin Invest. 2000. PMID: 10862788 Free PMC article.
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