Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death - PubMed (original) (raw)
Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death
T Opthof et al. Circulation. 2000.
Abstract
Background: Heart failure is associated with profound changes in the balance of the autonomic nervous system, such as vagal withdrawal and increased catecholamine levels. It is not known whether the intrinsic sinus node function changes during the progression of heart failure.
Methods and results: We implanted transmitters for Holter recording in an established rabbit model of heart failure (n=9) and observed changes in sinus cycle length and the occurrence of arrhythmias during the progression of heart failure. The in vitro sinus cycle length and the responses to acetylcholine and norepinephrine in the isolated right atria were analyzed in 12 rabbits with heart failure and in 6 control rabbits. In vivo cycle length increased in some animals and decreased in others. Sudden death occurred in 3 of 9 rabbits. These rabbits had developed a shorter cycle length than the surviving rabbits. Ventricular tachycardias developed in all but 1 rabbit. The in vitro sinus cycle length increased in heart failure. The response to acetylcholine also increased in heart failure, whereas the response to norepinephrine was unchanged.
Conclusions: Changes in intrinsic sinus node function during the progression of heart failure cannot explain the observed decreases in heart rate variability and/or baroreflex sensitivity in this disease, because increased responsiveness to acetylcholine would be expected to cause the opposite.
Similar articles
- Arrhythmogenesis in heart failure.
Janse MJ, Vermeulen JT, Opthof T, Coronel R, Wilms-Schopman FJ, Rademaker HM, Baartscheer A, Dekker LR. Janse MJ, et al. J Cardiovasc Electrophysiol. 2001 Apr;12(4):496-9. doi: 10.1046/j.1540-8167.2001.00496.x. J Cardiovasc Electrophysiol. 2001. PMID: 11332576 Review. - Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits.
Pogwizd SM. Pogwizd SM. Circulation. 1995 Aug 15;92(4):1034-48. doi: 10.1161/01.cir.92.4.1034. Circulation. 1995. PMID: 7543829 - Sinus node dysfunction--a physiologic consideration of arrhythmias involving the sinus node.
Goldreyer BN. Goldreyer BN. Cardiovasc Clin. 1974;6(1):179-98. Cardiovasc Clin. 1974. PMID: 4611612 Review. No abstract available. - Effects of repeated sauna treatment on ventricular arrhythmias in patients with chronic heart failure.
Kihara T, Biro S, Ikeda Y, Fukudome T, Shinsato T, Masuda A, Miyata M, Hamasaki S, Otsuji Y, Minagoe S, Akiba S, Tei C. Kihara T, et al. Circ J. 2004 Dec;68(12):1146-51. doi: 10.1253/circj.68.1146. Circ J. 2004. PMID: 15564698 Clinical Trial. - Cardiac electrical stunning is a common feature of cardiac arrhythmias.
Li G, Liu T, Liu E. Li G, et al. Med Hypotheses. 2006;67(4):865-7. doi: 10.1016/j.mehy.2006.03.045. Epub 2006 Jun 8. Med Hypotheses. 2006. PMID: 16759818
Cited by
- Desmosomal junctions are necessary for adult sinus node function.
Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Mezzano V, et al. Cardiovasc Res. 2016 Aug 1;111(3):274-86. doi: 10.1093/cvr/cvw083. Epub 2016 Apr 20. Cardiovasc Res. 2016. PMID: 27097650 Free PMC article. - Congestive heart failure: experimental model.
Corno AF, Cai X, Jones CB, Mondani G, Boyett MR, Jarvis JC, Hart G. Corno AF, et al. Front Pediatr. 2013 Oct 28;1:33. doi: 10.3389/fped.2013.00033. eCollection 2013. Front Pediatr. 2013. PMID: 24400279 Free PMC article. - Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit.
Logantha SJRJ, Cai XJ, Yanni J, Jones CB, Stephenson RS, Stuart L, Quigley G, Monfredi O, Nakao S, Oh IY, Starborg T, Kitmitto A, Vohra A, Hutcheon RC, Corno AF, Jarvis JC, Dobrzynski H, Boyett MR, Hart G. Logantha SJRJ, et al. Circ Heart Fail. 2021 Jul;14(7):e007505. doi: 10.1161/CIRCHEARTFAILURE.120.007505. Epub 2021 Jun 30. Circ Heart Fail. 2021. PMID: 34190577 Free PMC article. - Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling.
Xue JB, Val-Blasco A, Davoodi M, Gómez S, Yaniv Y, Benitah JP, Gómez AM. Xue JB, et al. J Gen Physiol. 2022 Sep 5;154(9):e202112895. doi: 10.1085/jgp.202112895. Epub 2022 Apr 22. J Gen Physiol. 2022. PMID: 35452507 Free PMC article. - RyR2 and Calcium Release in Heart Failure.
Benitah JP, Perrier R, Mercadier JJ, Pereira L, Gómez AM. Benitah JP, et al. Front Physiol. 2021 Oct 8;12:734210. doi: 10.3389/fphys.2021.734210. eCollection 2021. Front Physiol. 2021. PMID: 34690808 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical