Lysosome-related organelles - PubMed (original) (raw)

Review

. 2000 Jul;14(10):1265-78.

doi: 10.1096/fj.14.10.1265.

Affiliations

• PMID: 10877819
• DOI: 10.1096/fj.14.10.1265

Review

Lysosome-related organelles

E C Dell'Angelica et al. FASEB J. 2000 Jul.

Abstract

Lysosomes are membrane-bound cytoplasmic organelles involved in intracellular protein degradation. They contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most of the properties of lysosomes are shared with a group of cell type-specific compartments referred to as 'lysosome-related organelles', which include melanosomes, lytic granules, MHC class II compartments, platelet-dense granules, basophil granules, azurophil granules, and Drosophila pigment granules. In addition to lysosomal proteins, these organelles contain cell type-specific components that are responsible for their specialized functions. Abnormalities in both lysosomes and lysosome-related organelles have been observed in human genetic diseases such as the Chediak-Higashi and Hermansky-Pudlak syndromes, further demonstrating the close relationship between these organelles. Identification of genes mutated in these human diseases, as well as in mouse and Drosophila: pigmentation mutants, is beginning to shed light on the molecular machinery involved in the biogenesis of lysosomes and lysosome-related organelles.

PubMed Disclaimer

Similar articles

• Lysosomal Trafficking Regulator (LYST).
  Ji X, Chang B, Naggert JK, Nishina PM. Ji X, et al. Adv Exp Med Biol. 2016;854:745-50. doi: 10.1007/978-3-319-17121-0_99. Adv Exp Med Biol. 2016. PMID: 26427484
• Normal-sized primary lysosomes are present in Chediak-Higashi syndrome neutrophils.
  White JG, Krumwiede M. White JG, et al. Pediatr Res. 1987 Aug;22(2):208-15. doi: 10.1203/00006450-198708000-00022. Pediatr Res. 1987. PMID: 2821473
• Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics.
  Huizing M, Helip-Wooley A, Westbroek W, Gunay-Aygun M, Gahl WA. Huizing M, et al. Annu Rev Genomics Hum Genet. 2008;9:359-86. doi: 10.1146/annurev.genom.9.081307.164303. Annu Rev Genomics Hum Genet. 2008. PMID: 18544035 Free PMC article. Review.
• Hermansky-Pudlak syndrome and pale ear: melanosome-making for the millennium.
  Spritz RA. Spritz RA. Pigment Cell Res. 2000 Feb;13(1):15-20. doi: 10.1034/j.1600-0749.2000.130104.x. Pigment Cell Res. 2000. PMID: 10761991 Review.

Cited by

• Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.
  Wang X, Herberg FW, Laue MM, Wullner C, Hu B, Petrasch-Parwez E, Kilimann MW. Wang X, et al. J Neurosci. 2000 Dec 1;20(23):8551-65. doi: 10.1523/JNEUROSCI.20-23-08551.2000. J Neurosci. 2000. PMID: 11102458 Free PMC article.
• Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release.
  Ham H, Medlyn M, Billadeau DD. Ham H, et al. Front Immunol. 2022 Apr 26;13:871106. doi: 10.3389/fimmu.2022.871106. eCollection 2022. Front Immunol. 2022. PMID: 35558071 Free PMC article. Review.
• Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function.
  Sitaram A, Piccirillo R, Palmisano I, Harper DC, Dell'Angelica EC, Schiaffino MV, Marks MS. Sitaram A, et al. Mol Biol Cell. 2009 Mar;20(5):1464-77. doi: 10.1091/mbc.e08-07-0710. Epub 2008 Dec 30. Mol Biol Cell. 2009. PMID: 19116314 Free PMC article.
• Autophagy induced by calcium phosphate precipitates targets damaged endosomes.
  Chen X, Khambu B, Zhang H, Gao W, Li M, Chen X, Yoshimori T, Yin XM. Chen X, et al. J Biol Chem. 2014 Apr 18;289(16):11162-11174. doi: 10.1074/jbc.M113.531855. Epub 2014 Mar 11. J Biol Chem. 2014. PMID: 24619419 Free PMC article.
• Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols.
  Huang Y, Li Y, Hu Z, Yue X, Proetto MT, Jones Y, Gianneschi NC. Huang Y, et al. ACS Cent Sci. 2017 Jun 28;3(6):564-569. doi: 10.1021/acscentsci.6b00230. Epub 2017 May 18. ACS Cent Sci. 2017. PMID: 28691067 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase

• Research Materials

  • NCI CPTC Antibody Characterization Program