Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells - PubMed (original) (raw)

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells

A Herreman et al. Nat Cell Biol. 2000 Jul.

No abstract available

PubMed Disclaimer

Similar articles

• Alzheimer's disease. Closing in on gamma-secretase.
  De Strooper B. De Strooper B. Nature. 2000 Jun 8;405(6787):627, 629. doi: 10.1038/35015193. Nature. 2000. PMID: 10864307 No abstract available.
• Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
  Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Zhang Z, et al. Nat Cell Biol. 2000 Jul;2(7):463-5. doi: 10.1038/35017108. Nat Cell Biol. 2000. PMID: 10878814 No abstract available.
• Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
  Alves da Costa C, Ayral E, Hernandez JF, St George-Hyslop P, Checler F. Alves da Costa C, et al. J Neurochem. 2004 Aug;90(4):800-6. doi: 10.1111/j.1471-4159.2004.02512.x. J Neurochem. 2004. PMID: 15287885
• [Alzheimer's disease: focus on beta-amyloid and gamma-secretase].
  Iwatsubo T. Iwatsubo T. Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1086-90. Tanpakushitsu Kakusan Koso. 2004. PMID: 15168534 Review. Japanese. No abstract available.
• Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
  Selkoe DJ. Selkoe DJ. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. doi: 10.1073/pnas.211352598. Proc Natl Acad Sci U S A. 2001. PMID: 11572965 Free PMC article. Review.

Cited by

• The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.
  Vaillant-Beuchot L, Eysert F, Duval B, Kinoshita PF, Pardossi-Piquard R, Bauer C, Eddarkaoui S, Buée L, Checler F, Chami M. Vaillant-Beuchot L, et al. Cell Death Dis. 2024 May 28;15(5):367. doi: 10.1038/s41419-024-06742-2. Cell Death Dis. 2024. PMID: 38806484 Free PMC article.
• Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform.
  Odorčić I, Hamed MB, Lismont S, Chávez-Gutiérrez L, Efremov RG. Odorčić I, et al. Nat Commun. 2024 May 27;15(1):4479. doi: 10.1038/s41467-024-48776-2. Nat Commun. 2024. PMID: 38802343 Free PMC article.
• Selective inhibitors of the PSEN1-gamma-secretase complex.
  Serneels L, Narlawar R, Perez-Benito L, Municoy M, Guallar V, T'Syen D, Dewilde M, Bischoff F, Fraiponts E, Tresadern G, Roevens PWM, Gijsen HJM, De Strooper B. Serneels L, et al. J Biol Chem. 2023 Jun;299(6):104794. doi: 10.1016/j.jbc.2023.104794. Epub 2023 May 9. J Biol Chem. 2023. PMID: 37164155 Free PMC article.
• Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
  Petit D, Hitzenberger M, Koch M, Lismont S, Zoltowska KM, Enzlein T, Hopf C, Zacharias M, Chávez-Gutiérrez L. Petit D, et al. EMBO J. 2022 Nov 2;41(21):e111084. doi: 10.15252/embj.2022111084. Epub 2022 Sep 19. EMBO J. 2022. PMID: 36121025 Free PMC article.
• Parkin as a Molecular Bridge Linking Alzheimer's and Parkinson's Diseases?
  Checler F, Alves da Costa C. Checler F, et al. Biomolecules. 2022 Apr 9;12(4):559. doi: 10.3390/biom12040559. Biomolecules. 2022. PMID: 35454148 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information