Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity - PubMed (original) (raw)

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity

M Yan et al. Nat Immunol. 2000 Jul.

Abstract

B lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) superfamily. BLyS stimulates proliferation of, and immunoglobulin production by, B cells. However, the relative importance of BLyS in physiological B cell activation is unclear. We identified a B cell receptor for BLyS through expression cloning as TACI, an orphan TNF receptor homologue of unknown function. Binding of BLyS to TACI activated signaling by nuclear factor-kappa B (NF-kappa B). In vitro soluble TACI-Fc fusion protein blocked BLyS-induced NF-kappa B activation in B lymphoma cells and IgM production in peripheral blood B cells. In vivo treatment of immunized mice with TACI-Fc inhibited production of antigen-specific IgM and IgGI antibodies and abolished splenic germinal center (GC) formation. Thus, BLyS activity must play a critical role in the humoral immune response.

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Comment in

• Secreted IgM versus BLyS in germinal center formation.
  Baumgarth N. Baumgarth N. Nat Immunol. 2000 Sep;1(3):179. doi: 10.1038/79708. Nat Immunol. 2000. PMID: 10973267 No abstract available.

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