Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor - PubMed (original) (raw)
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor
V S Spiegelman et al. Mol Cell. 2000 May.
Free article
Abstract
Beta-transducing repeat-containing protein (betaTrCP) targets the ubiquitination and subsequent degradation of both beta-catenin and IkappaB, thereby playing an important role in beta-catenin/Tcf and NF-kappaB-dependent signaling. Here evidence is presented that beta-catenin/Tcf signaling elevates the expression of betaTrCP mRNA and protein in a Tcf-dependent manner, which does not require betaTrCP transcription. Induction of betaTrCP expression by the beta-catenin/Tcf pathway results in an accelerated degradation of the wild-type beta-catenin, suggesting that the negative feedback loop regulation may control the beta-catenin/Tcf pathway. This signaling also upregulated NF-kappaB transactivation without affecting the activity of IkappaB kinase, thereby establishing that the maintenance of the betaTrCP level is important for coordination between beta-catenin/Tcf and NF-kappaB signaling.
Similar articles
- Inhibition of HOS expression and activities by Wnt pathway.
Spiegelman VS, Tang W, Katoh M, Slaga TJ, Fuchs SY. Spiegelman VS, et al. Oncogene. 2002 Jan 24;21(5):856-60. doi: 10.1038/sj.onc.1205132. Oncogene. 2002. PMID: 11850814 - HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.
Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z. Fuchs SY, et al. Oncogene. 1999 Mar 25;18(12):2039-46. doi: 10.1038/sj.onc.1202760. Oncogene. 1999. PMID: 10321728 - TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.
Brantjes H, Barker N, van Es J, Clevers H. Brantjes H, et al. Biol Chem. 2002 Feb;383(2):255-61. doi: 10.1515/BC.2002.027. Biol Chem. 2002. PMID: 11934263 Review. - TCF transcription factors: molecular switches in carcinogenesis.
Roose J, Clevers H. Roose J, et al. Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37. doi: 10.1016/s0304-419x(99)00026-8. Biochim Biophys Acta. 1999. PMID: 10528152 Review.
Cited by
- Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives.
Moore G, Annett S, McClements L, Robson T. Moore G, et al. Cells. 2020 Jun 20;9(6):1503. doi: 10.3390/cells9061503. Cells. 2020. PMID: 32575680 Free PMC article. Review. - The Wnt signaling pathway and its role in tumor development.
Lustig B, Behrens J. Lustig B, et al. J Cancer Res Clin Oncol. 2003 Apr;129(4):199-221. doi: 10.1007/s00432-003-0431-0. Epub 2003 Apr 18. J Cancer Res Clin Oncol. 2003. PMID: 12707770 Review. - The roles of E3 ubiquitin ligases in cancer progression and targeted therapy.
Sampson C, Wang Q, Otkur W, Zhao H, Lu Y, Liu X, Piao HL. Sampson C, et al. Clin Transl Med. 2023 Mar;13(3):e1204. doi: 10.1002/ctm2.1204. Clin Transl Med. 2023. PMID: 36881608 Free PMC article. Review. - Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway.
Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A. Bachar-Dahan L, et al. Mol Biol Cell. 2006 Jun;17(6):2572-80. doi: 10.1091/mbc.e06-01-0052. Epub 2006 Mar 29. Mol Biol Cell. 2006. PMID: 16571670 Free PMC article. - NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.
Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. Guo F, et al. Sci Rep. 2021 Aug 12;11(1):16409. doi: 10.1038/s41598-021-95720-1. Sci Rep. 2021. PMID: 34385484 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous