Notch signal transduction: a real rip and more - PubMed (original) (raw)

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Notch signal transduction: a real rip and more

G Weinmaster. Curr Opin Genet Dev. 2000 Aug.

Abstract

The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

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