Stepwise specification of lymphocyte developmental lineages - PubMed (original) (raw)
Review
Stepwise specification of lymphocyte developmental lineages
E V Rothenberg. Curr Opin Genet Dev. 2000 Aug.
Abstract
B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.
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