Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth - PubMed (original) (raw)

. 2000 Jul 1;96(1):259-63.

Affiliations

• PMID: 10891459

Free article

Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth

C X Wang et al. Blood. 2000.

Free article

Abstract

Fizzy-related (fzr) is a recently identified 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. In this study, the murine homologue of fzr was isolated by suppression subtractive hybridization as a gene with decreased expression during malignant progression of a murine B-lymphoma cell line. Retroviral overexpression of fzr in B-lymphoma cells reduced tumor formation. Those tumors that did arise had diminished or extinguished retroviral Fzr. Surprisingly, fzr overexpression dramatically increased B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity, a host-resistant mechanism for tumor formation in this model system. These findings implicate fzr as a new category of genes suppressing B-cell tumorigenesis and suggest a novel role for fzr in the target cell interaction with NK cells.

PubMed Disclaimer

Similar articles

• Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog.
  Jacobs H, Richter D, Venkatesh T, Lehner C. Jacobs H, et al. Curr Biol. 2002 Aug 20;12(16):1435-41. doi: 10.1016/s0960-9822(02)01074-6. Curr Biol. 2002. PMID: 12194827
• The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels.
  Inbal N, Listovsky T, Brandeis M. Inbal N, et al. FEBS Lett. 1999 Dec 17;463(3):350-4. doi: 10.1016/s0014-5793(99)01640-3. FEBS Lett. 1999. PMID: 10606752
• Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2.
  Grosskortenhaus R, Sprenger F. Grosskortenhaus R, et al. Dev Cell. 2002 Jan;2(1):29-40. doi: 10.1016/s1534-5807(01)00104-6. Dev Cell. 2002. PMID: 11782312
• Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
  Chowdhury SR, Koley T, Singh M, Ethayathulla AS, Kaur P. Chowdhury SR, et al. Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188883. doi: 10.1016/j.bbcan.2023.188883. Epub 2023 Mar 25. Biochim Biophys Acta Rev Cancer. 2023. PMID: 36972769 Review.
• A genetic modifier screen identifies multiple genes that interact with Drosophila Rap/Fzr and suggests novel cellular roles.
  Kaplow ME, Mannava LJ, Pimentel AC, Fermin HA, Hyatt VJ, Lee JJ, Venkatesh TR. Kaplow ME, et al. J Neurogenet. 2007 Jul-Sep;21(3):105-51. doi: 10.1080/01677060701503140. J Neurogenet. 2007. PMID: 17849284 Review.

Cited by

• Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
  Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP. Song MS, et al. Cell. 2011 Jan 21;144(2):187-99. doi: 10.1016/j.cell.2010.12.020. Cell. 2011. PMID: 21241890 Free PMC article.
• Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism.
  Ros S, Schulze A. Ros S, et al. Cancer Metab. 2013 Feb 4;1(1):8. doi: 10.1186/2049-3002-1-8. Cancer Metab. 2013. PMID: 24280138 Free PMC article.
• The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
  Wäsch R, Robbins JA, Cross FR. Wäsch R, et al. Oncogene. 2010 Jan 7;29(1):1-10. doi: 10.1038/onc.2009.325. Epub 2009 Oct 12. Oncogene. 2010. PMID: 19826416 Free PMC article. Review.
• E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation.
  Almeida A, Bolaños JP, Moncada S. Almeida A, et al. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):738-41. doi: 10.1073/pnas.0913668107. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2010. PMID: 20080744 Free PMC article.
• Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities.
  Wan Y, Kirschner MW. Wan Y, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13066-71. doi: 10.1073/pnas.231487598. Epub 2001 Oct 30. Proc Natl Acad Sci U S A. 2001. PMID: 11687641 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)