Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype - PubMed (original) (raw)
. 2000 Jul 12;55(1):134-6.
doi: 10.1212/wnl.55.1.134.
Affiliations
- PMID: 10891924
- DOI: 10.1212/wnl.55.1.134
Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype
S D Moffat et al. Neurology. 2000.
Abstract
The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE epsilon4 allele may show a greater rate of hippocampal atrophy than their epsilon4- counterparts, even in the absence of a diagnosis of AD.
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