Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype - PubMed (original) (raw)
. 2000 Jul 12;55(1):134-6.
doi: 10.1212/wnl.55.1.134.
Affiliations
- PMID: 10891924
- DOI: 10.1212/wnl.55.1.134
Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype
S D Moffat et al. Neurology. 2000.
Abstract
The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE epsilon4 allele may show a greater rate of hippocampal atrophy than their epsilon4- counterparts, even in the absence of a diagnosis of AD.
Similar articles
- [Study of relationship between ApoE epsilon4 allele and hippocampal atrophy in Alzheimer disease].
Li J, Kuang WH, Li J, Wang X, Huang MS, Wu DP. Li J, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jan;36(1):50-2. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005. PMID: 15702779 Chinese. - Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.
Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT. Barber R, et al. Arch Neurol. 1999 Aug;56(8):961-5. doi: 10.1001/archneur.56.8.961. Arch Neurol. 1999. PMID: 10448801 - APOE genotype and hippocampal volume change in geriatric depression.
Kim DH, Payne ME, Levy RM, MacFall JR, Steffens DC. Kim DH, et al. Biol Psychiatry. 2002 Mar 1;51(5):426-9. doi: 10.1016/s0006-3223(01)01272-0. Biol Psychiatry. 2002. PMID: 11904138 - Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.
Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E. Jack CR Jr, et al. Ann Neurol. 1998 Mar;43(3):303-10. doi: 10.1002/ana.410430307. Ann Neurol. 1998. PMID: 9506546 Free PMC article. Review. - Imaging studies and APOE genotype in persons at risk for Alzheimer's disease.
Scarmeas N, Stern Y. Scarmeas N, et al. Curr Psychiatry Rep. 2006 Feb;8(1):11-7. doi: 10.1007/s11920-006-0076-1. Curr Psychiatry Rep. 2006. PMID: 16513038 Free PMC article. Review.
Cited by
- Imaging the progression of Alzheimer pathology through the brain.
Smith AD. Smith AD. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4135-7. doi: 10.1073/pnas.082107399. Proc Natl Acad Sci U S A. 2002. PMID: 11929987 Free PMC article. No abstract available. - Different susceptibility of medial temporal lobe and basal ganglia atrophy rates to vascular risk factors.
de Jong LW, Forsberg LE, Vidal JS, Sigurdsson S, Zijdenbos AP, Garcia M, Eiriksdottir G, Gudnason V, van Buchem MA, Launer LJ. de Jong LW, et al. Neurobiol Aging. 2014 Jan;35(1):72-8. doi: 10.1016/j.neurobiolaging.2013.07.009. Epub 2013 Aug 28. Neurobiol Aging. 2014. PMID: 23992618 Free PMC article. - Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype.
Mishra S, Blazey TM, Holtzman DM, Cruchaga C, Su Y, Morris JC, Benzinger TLS, Gordon BA. Mishra S, et al. Brain. 2018 Jun 1;141(6):1828-1839. doi: 10.1093/brain/awy103. Brain. 2018. PMID: 29672664 Free PMC article. - Protective Effect of Human Leukocyte Antigen (HLA) Allele DRB1*13:02 on Age-Related Brain Gray Matter Volume Reduction in Healthy Women.
James LM, Christova P, Lewis SM, Engdahl BE, Georgopoulos A, Georgopoulos AP. James LM, et al. EBioMedicine. 2018 Mar;29:31-37. doi: 10.1016/j.ebiom.2018.02.005. Epub 2018 Feb 8. EBioMedicine. 2018. PMID: 29452862 Free PMC article. - Alzheimer's disease genetic risk and changes in brain atrophy and white matter hyperintensities in cognitively unimpaired adults.
Soldan A, Wang J, Pettigrew C, Davatzikos C, Erus G, Hohman TJ, Dumitrescu L, Bilgel M, Resnick SM, Rivera-Rivera LA, Langhough R, Johnson SC, Benzinger T, Morris JC, Laws SM, Fripp J, Masters CL, Albert MS. Soldan A, et al. Brain Commun. 2024 Aug 14;6(5):fcae276. doi: 10.1093/braincomms/fcae276. eCollection 2024. Brain Commun. 2024. PMID: 39229494 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous